WBC, URINE

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VeDDRA Code: 99373

378 adverse event reports referencing this reaction

378
Total Reports
65
Deaths
1720.0%
Death Rate

Species Most Affected

Dog 335
Cat 42
Horse 1

Breeds Most Affected

Retriever - Labrador 65
Crossbred Canine/dog 38
Domestic Shorthair 17
Retriever - Golden 16
Domestic (unspecified) 16
Boxer (German Boxer) 15
Shih Tzu 11
Shepherd Dog - German 10
Shepherd Dog - Australian 7
Siberian Husky 6

Associated Drugs

Carprofen 58
Trilostane 34
Deracoxib 27
Oclacitinib Maleate 27
Meloxicam 25
Milbemycin Oxime + Spinosad 22
Maropitant Citrate 16
Afoxolaner 16
Spinosad 15
Moxidectin 13
Tramadol 12
Pyrantel Pamoate;Sarolaner 12
Cefovecin Sodium 11
Firocoxib 10
Ivermectin + Pyrantel As Pamoate Salt 10
Fluralaner Chew Tablets 9
Recombinant E. Coli Bl21;Recombinant E. Coli Ecl19 9
Cyclosporine 8
Grapiprant 8
Lotilaner 8

Data Summary

Metric Value
Total reports referencing reaction 378
Reports with fatal outcome 65
Case-fatality rate (reported events) 1720.0%
Species observed 3
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 99373.

WBC, URINE Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 378 adverse event reports that reference WBC, URINE as a reaction term, including 65 reports with a death outcome — a 1720.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 99373, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

WBC, URINE appears most frequently in reports for Dog (335 reports), Cat (42 reports), Horse (1 reports) — with Dog dominating at 335 entries. Within those species, the breeds most often named alongside this reaction are Retriever - Labrador (65), Crossbred Canine/dog (38), Domestic Shorthair (17). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with WBC, URINE are Carprofen (58 reports), Trilostane (34 reports), Deracoxib (27 reports), Oclacitinib Maleate (27 reports), with Carprofen appearing alongside this reaction in 58 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial