Abnormal test result

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VeDDRA Code: 1221

377 adverse event reports referencing this reaction

377
Total Reports
127
Deaths
3370.0%
Death Rate

Species Most Affected

Dog 235
Cattle 124
Cat 14
Pig 2
Sheep 1
Horse 1

Breeds Most Affected

Cattle (other) 64
Retriever - Labrador 35
Mixed (Cattle) 35
Retriever - Golden 18
Shepherd Dog - German 14
Beagle 14
Holstein-Friesian also known as Holstein 11
Crossbred Canine/dog 11
Shih Tzu 9
Domestic Shorthair 8

Associated Drugs

Ivermectin + Pyrantel As Pamoate Salt 127
Ceftiofur Crystalline Free Acid 71
Bovine Parainfluenza Virus 3 (Ts), Rlb103 (Nl-Bk-6), Mlv; Bovine Respiratory Syn 51
Bovine Respiratory Syncytial Virus, 597-10 10Th Psg Strain 375; Bovine Viral Dia 48
Tulathromycin 42
Bovine Viral Diarrhea Virus, Type 2, Strain 53637, Lot Bvd2Mlv-D; Bovine Viral D 26
Milbemycin Oxime, Lufenuron 22
Bovine Parainfluenza Virus 3, Reisinger(Nl-Bk-6), Mlv; Bovine Respiratory Syncyt 21
Clostridium Chauvoei, Strain F, Lot No. 2-84; Clostridium Novyi, 8296, Kb; Clost 18
Doramectin; Phenol 15
Doramectin 10
Bovine Parainfluenza Virus 3 (Ts), Rlb103 (Nl-Bk-6), Mlv; Infectious Bovine Rhin 10
Milbemcyin Oxime, Lufenuron, Praziquantel 10
Albendazole 9
Recombinant Human Insulin 9
Maropitant Citrate 7
Metronidazole 7
Fluralaner Chew Tablets 7
Imidacloprid + Moxidectin 6
Oclacitinib Maleate 6

Data Summary

Metric Value
Total reports referencing reaction 377
Reports with fatal outcome 127
Case-fatality rate (reported events) 3370.0%
Species observed 6
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 1221.

Abnormal test result Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 377 adverse event reports that reference Abnormal test result as a reaction term, including 127 reports with a death outcome — a 3370.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 1221, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Abnormal test result appears most frequently in reports for Dog (235 reports), Cattle (124 reports), Cat (14 reports) — with Dog dominating at 235 entries. Within those species, the breeds most often named alongside this reaction are Cattle (other) (64), Retriever - Labrador (35), Mixed (Cattle) (35). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Abnormal test result are Ivermectin + Pyrantel As Pamoate Salt (127 reports), Ceftiofur Crystalline Free Acid (71 reports), Bovine Parainfluenza Virus 3 (Ts), Rlb103 (Nl-Bk-6), Mlv; Bovine Respiratory Syn (51 reports), Bovine Respiratory Syncytial Virus, 597-10 10Th Psg Strain 375; Bovine Viral Dia (48 reports), with Ivermectin + Pyrantel As Pamoate Salt appearing alongside this reaction in 127 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial