Reaction profile

The FDA adverse-event record for periodontal disorder

122 FDA adverse-event reports reference periodontal disorder (VeDDRA 2225). See the species, breeds, and drugs most associated with it below.

122
reports citing this reaction
20.5%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
122
Total Reports
25
Deaths
20.5%
Death Rate

Species Most Affected

Dog 97
Cat 25

Breeds Most Affected

Domestic Shorthair 15
Chihuahua 7
Retriever - Labrador 6
Shih Tzu 5
Beagle 5
Crossbred Canine/dog 5
Maltese 5
Terrier (unspecified) 5
Dog (unknown) 5
Dachshund (unspecified) 4

Associated Drugs

Milbemycin Oxime + Spinosad 28
Trilostane 20
Spinosad 10
Afoxolaner 8
Fluralaner 7
Maropitant Citrate 7
Milbemycin Oxime + Praziquantel 7
Gabapentin 7
Buprenorphine 7
Rabies Vaccine 6
Ivermectin 6
Insulin Injectable Vial 6
Butorphanol 6
Oclacitinib Maleate 5
Ivermectin + Pyrantel As Pamoate Salt 5
Cyclosporine 5
Robenacoxib 5
Mirtazapine 5
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 5
Carprofen 5

Periodontal disorder Reaction Insights

122 reports name Periodontal disorder; 25 recorded a death outcome (20.5% of reported events, not a population-level mortality rate). VeDDRA code: 2225.

By species: Dog (97 reports), Cat (25 reports). By breed: Domestic Shorthair (15), Chihuahua (7), Retriever - Labrador (6).

Most co-reported drugs: Milbemycin Oxime + Spinosad (28 reports), Trilostane (20 reports), Spinosad (10 reports), Afoxolaner (8 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.