Reaction profile

The FDA adverse-event record for urolithiasis

317 FDA adverse-event reports reference urolithiasis (VeDDRA 740). See the species, breeds, and drugs most associated with it below.

317
reports citing this reaction
18.9%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
317
Total Reports
60
Deaths
18.9%
Death Rate

Species Most Affected

Dog 281
Cat 32
Horse 2
Sheep 1
Goat 1

Breeds Most Affected

Shih Tzu 25
Schnauzer - Miniature 19
Domestic Shorthair 19
Terrier - Yorkshire 19
Maltese 17
Bichon Frise 15
Crossbred Canine/dog 15
Chihuahua 13
Pug 11
Retriever - Labrador 11

Associated Drugs

Milbemycin Oxime + Spinosad 64
Trilostane 44
Oclacitinib Maleate 33
Spinosad 22
Afoxolaner 17
Gabapentin 13
Fluralaner Chew Tablets 13
Bedinvetmab 13
Cefovecin 12
Maropitant Citrate 12
Ivermectin + Pyrantel As Pamoate Salt 11
Meloxicam 9
Carprofen 9
Enrofloxacin 9
Milbemycin Oxime + Praziquantel 9
Ivermectin 8
Moxidectin 8
Buprenorphine 8
Prednisone 7
Insulin Injectable Vial 7

Urolithiasis Reaction Insights

317 reports name Urolithiasis; 60 recorded a death outcome (18.9% of reported events, not a population-level mortality rate). VeDDRA code: 740.

By species: Dog (281 reports), Cat (32 reports), Horse (2 reports). By breed: Shih Tzu (25), Schnauzer - Miniature (19), Domestic Shorthair (19).

Most co-reported drugs: Milbemycin Oxime + Spinosad (64 reports), Trilostane (44 reports), Oclacitinib Maleate (33 reports), Spinosad (22 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.