Reaction profile

The FDA adverse-event record for granuloma

124 FDA adverse-event reports reference granuloma (VeDDRA 950). See the species, breeds, and drugs most associated with it below.

124
reports citing this reaction
11.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
124
Total Reports
14
Deaths
11.3%
Death Rate

Species Most Affected

Dog 93
Cat 22
Horse 5
Rabbit 3
Cattle 1

Breeds Most Affected

Domestic Shorthair 10
Retriever - Labrador 9
Dachshund (unspecified) 6
Shepherd Dog - German 6
Dog (unknown) 5
Crossbred Canine/dog 4
Domestic (unspecified) 4
Retriever - Golden 4
Doberman Pinscher 3
Shepherd Dog - Australian 3

Associated Drugs

Milbemycin Oxime + Spinosad 19
Oclacitinib Maleate 14
Carprofen 9
Prednisone 8
Moxidectin 7
Bedinvetmab 7
Imidacloprid + Moxidectin 6
Meloxicam 6
Cyclosporine A 5
Milbemycin Oxime + Praziquantel 5
Gabapentin 5
Cyclosporine 4
Amoxicillin, Clavulanate 4
Spinosad 4
Prednisolone 4
Polysulfated Glycosaminoglycan 4
Selamectin 3
Flumethrin-Imidacloprid 3
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 3
Water, Sodium Chloride, Sodium Lactate, Potassium Chloride, Calcium Chloride 3

Granuloma Reaction Insights

124 reports name Granuloma; 14 recorded a death outcome (11.3% of reported events, not a population-level mortality rate). VeDDRA code: 950.

By species: Dog (93 reports), Cat (22 reports), Horse (5 reports). By breed: Domestic Shorthair (10), Retriever - Labrador (9), Dachshund (unspecified) (6).

Most co-reported drugs: Milbemycin Oxime + Spinosad (19 reports), Oclacitinib Maleate (14 reports), Carprofen (9 reports), Prednisone (8 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.