Hepatic necrosis
VeDDRA Code: 491
129 adverse event reports referencing this reaction
129
Total Reports
105
Deaths
8140.0%
Death Rate
Species Most Affected
Dog 93
Cattle 23
Cat 9
Bison 1
Horse 1
Sheep 1
Goat 1
Breeds Most Affected
Retriever - Labrador 19
Domestic Shorthair 8
Crossbred Canine/dog 6
Cattle (unknown) 5
Holstein-Friesian also known as Holstein 4
Retriever - Golden 4
Shepherd Dog - German 4
Havanese 4
Shepherd Dog - Australian 3
Dachshund (unspecified) 3
Associated Drugs
Carprofen 24
Monensin Sodium 14
Maropitant Citrate 14
Milbemycin Oxime + Spinosad 12
Fluralaner Chew Tablets 11
Famotidine 10
Gabapentin 9
Afoxolaner 9
Tramadol 7
Sam-E, Silybin, Vitamin E, Zinc 7
Oclacitinib Maleate 7
Imidacloprid + Moxidectin 6
Ivermectin + Pyrantel As Pamoate Salt 6
Rabies Vaccine 6
Bordetella Vaccine 5
Buprenorphine 5
Ampicillin 5
Ivermectin 5
Prednisone 5
Cyclosporine 5
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.