Reaction profile

The FDA adverse-event record for oral pain

58 FDA adverse-event reports reference oral pain (VeDDRA 1660). See the species, breeds, and drugs most associated with it below.

58
reports citing this reaction
12.1%
death-coded share
Dog
most-affected species
Cyclosporine A
most-associated drug
Verify with FDA CVM →
58
Total Reports
7
Deaths
12.1%
Death Rate

Species Most Affected

Dog 38
Cat 12
Human 5
Horse 3

Breeds Most Affected

Domestic Shorthair 6
Unknown 5
Chihuahua 4
Retriever - Labrador 4
Dachshund (unspecified) 2
Terrier - Yorkshire 2
Crossbred Canine/dog 2
Thoroughbred 2
Hound - Basset 2
Cat (unknown) 2

Associated Drugs

Cyclosporine A 9
Milbemycin Oxime + Spinosad 8
Cyclosporine 5
Afoxolaner 4
Neometeoryl Transruminal & Oral Solution 4
Carprofen 3
Maropitant Citrate 3
Anti-Il31 Mab Mcs Lot #1283563 3
Buprenorphine 3
Velagliflozin Proline Monohydrate 3
Deracoxib 2
Sucralfate 2
Famotidine 2
Subcutaneous Fluids 2
Prednisone 2
Pradofloxacin 2
Fluids 2
Fluralaner Chew Tablets 2
Moxidectin 2
Emodepside + Praziquantel 1

Oral pain Reaction Insights

58 reports name Oral pain; 7 recorded a death outcome (12.1% of reported events, not a population-level mortality rate). VeDDRA code: 1660.

By species: Dog (38 reports), Cat (12 reports), Human (5 reports). By breed: Domestic Shorthair (6), Unknown (5), Chihuahua (4).

Most co-reported drugs: Cyclosporine A (9 reports), Milbemycin Oxime + Spinosad (8 reports), Cyclosporine (5 reports), Afoxolaner (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.