Reaction profile

The FDA adverse-event record for oral pain

61 FDA adverse-event reports reference oral pain (VeDDRA 1660). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1649 of 2,481
by report volume (all reactions)
61
reports citing this reaction
13.1%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Oral pain has 61 reports now versus 61 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Oral pain changes

FDA AER · VeDDRA plate

Code 1660 VOL-LOW

VOL-LOW · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 61 reports
  • DEATH-ELEV 13.1%
  • MID-PACK #1649/2481
  • PHOTO-FINISH Injection site numbne…
  • SPECIES-DOG Dog · 41
  • DRUG-LEAD Cyclosporine A · 9
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Injection site numbness (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Oral pain

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Injection site numbne… · near61Intussusception · near61Oral pain · this reaction61Paraplegia · near61Retinal haemorrhage · near61Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Oral pain

What the FDA AER plate says about Oral pain

Signature read: report volume at 61 (#1649 of 2,481) is the standout scale stamp on Oral pain. Report volume sits in the middle third of the reaction corpus. 8 of 61 reports were death-coded (13.1% of named reports, not a population mortality rate). Nearest volume peer: Injection site numbness (±0 reports). Lead species Dog (41). Lead co-reported drug Cyclosporine A (9).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Cyclosporine A appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 41
Cat 12
Human 5
Horse 3

Breeds Most Affected

Domestic Shorthair 6
Unknown 5
Chihuahua 4
Retriever - Labrador 4
Dachshund (unspecified) 2
Terrier - Yorkshire 2
Crossbred Canine/dog 2
Thoroughbred 2
Hound - Basset 2
Cat (unknown) 2

Associated Drugs

Cyclosporine A 9
Milbemycin Oxime + Spinosad 8
Cyclosporine 5
Carprofen 4
Afoxolaner 4
Neometeoryl Transruminal & Oral Solution 4
Maropitant Citrate 3
Anti-Il31 Mab Mcs Lot #1283563 3
Buprenorphine 3
Velagliflozin Proline Monohydrate 3
Deracoxib 2
Sucralfate 2
Famotidine 2
Subcutaneous Fluids 2
Prednisone 2
Pradofloxacin 2
Fluids 2
Fluralaner Chew Tablets 2
Milbemycin Oxime + Praziquantel 2
Moxidectin 2

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Oral pain, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (61 here).

Similar death-coded share

Nearest other reactions by death-coded share (13.1% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Oral pain (#1649 of 2,481 by report volume); death-coded 13.1%. PlainBreed reaction plate · report volume stamp 61 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →