Reaction profile

The FDA adverse-event record for decreased drinking

1,178 FDA adverse-event reports reference decreased drinking (VeDDRA 2500). See the species, breeds, and drugs most associated with it below.

1,178
reports citing this reaction
13.2%
death-coded share
Dog
most-affected species
Fluralaner Chew Tablets
most-associated drug
Verify with FDA CVM →
1,178
Total Reports
155
Deaths
13.2%
Death Rate

Species Most Affected

Dog 888
Cat 270
Horse 9
Chicken 4
Cattle 2
Pig 2
Rabbit 2
Turkey 1

Breeds Most Affected

Domestic Shorthair 174
Crossbred Canine/dog 99
Retriever - Labrador 98
Chihuahua 49
Shih Tzu 46
Retriever - Golden 33
Shepherd Dog - German 32
Maltese 31
Terrier - Yorkshire 30
Pit Bull 23

Associated Drugs

Fluralaner Chew Tablets 102
Trilostane 91
Fluralaner 13.64% 12-Week Chew 74
Cefovecin 56
Pyrantel Pamoate;Sarolaner 55
Afoxolaner 53
Maropitant Citrate 53
Carprofen 51
Moxidectin 44
Bedinvetmab 41
Fluralaner Spot-On Solution 40
Milbemycin Oxime + Praziquantel 38
Oclacitinib Maleate 37
Buprenorphine 37
Gabapentin 37
Milbemycin Oxime + Spinosad 36
Selamectin 33
Sarolaner 30
Nitenpyram 29
Prednisone 27

Decreased drinking Reaction Insights

1,178 reports name Decreased drinking; 155 recorded a death outcome (13.2% of reported events, not a population-level mortality rate). VeDDRA code: 2500.

By species: Dog (888 reports), Cat (270 reports), Horse (9 reports). By breed: Domestic Shorthair (174), Crossbred Canine/dog (99), Retriever - Labrador (98).

Most co-reported drugs: Fluralaner Chew Tablets (102 reports), Trilostane (91 reports), Fluralaner 13.64% 12-Week Chew (74 reports), Cefovecin (56 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.