Reaction profile

The FDA adverse-event record for skin and/or appendage neoplasm nos

284 FDA adverse-event reports reference skin and/or appendage neoplasm nos (VeDDRA 922). See the species, breeds, and drugs most associated with it below.

284
reports citing this reaction
13.4%
death-coded share
Dog
most-affected species
Oclacitinib Maleate
most-associated drug
Verify with FDA CVM →
284
Total Reports
38
Deaths
13.4%
Death Rate

Species Most Affected

Dog 265
Cat 19

Breeds Most Affected

Retriever - Labrador 36
Retriever - Golden 20
Terrier - Bull - American Pit 15
Crossbred Canine/dog 14
Boxer (German Boxer) 13
Beagle 11
Shih Tzu 9
Shepherd Dog - German 9
Domestic (unspecified) 7
Lhasa Apso 7

Associated Drugs

Oclacitinib Maleate 133
Cyclosporine 45
Cyclosporine A 34
Milbemycin Oxime + Spinosad 26
Anti-Il31 Mab Mcs Lot #1283563 13
Trilostane 12
Prednisone 10
Carprofen 9
Cefpodoxime Proxetil 9
Cefovecin Sodium 8
Cephalexin 8
Ketoconazole 6
Gabapentin 6
Enrofloxacin 5
Spinosad 5
Cefovecin 5
Ivermectin 5
Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) 5
Afoxolaner 5
Anesthetic 5

Skin and/or appendage neoplasm NOS Reaction Insights

284 reports name Skin and/or appendage neoplasm NOS; 38 recorded a death outcome (13.4% of reported events, not a population-level mortality rate). VeDDRA code: 922.

By species: Dog (265 reports), Cat (19 reports). By breed: Retriever - Labrador (36), Retriever - Golden (20), Terrier - Bull - American Pit (15).

Most co-reported drugs: Oclacitinib Maleate (133 reports), Cyclosporine (45 reports), Cyclosporine A (34 reports), Milbemycin Oxime + Spinosad (26 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.