Reaction profile

The FDA adverse-event record for myoclonic jerk

289 FDA adverse-event reports reference myoclonic jerk (VeDDRA 1631). See the species, breeds, and drugs most associated with it below.

289
reports citing this reaction
8.0%
death-coded share
Dog
most-affected species
Sarolaner
most-associated drug
Verify with FDA CVM →
289
Total Reports
23
Deaths
8.0%
Death Rate

Species Most Affected

Dog 271
Cat 16
Human 1
Horse 1

Breeds Most Affected

Terrier - Yorkshire 26
Retriever - Labrador 22
Crossbred Canine/dog 19
Retriever - Golden 16
Shih Tzu 12
Chihuahua 11
Domestic Shorthair 11
Maltese 10
Shepherd Dog - Australian 10
Dachshund (unspecified) 10

Associated Drugs

Sarolaner 52
Afoxolaner 44
Pyrantel Pamoate;Sarolaner 30
Milbemycin Oxime + Spinosad 23
Fluralaner 13.64% 12-Week Chew 23
Ivermectin + Pyrantel As Pamoate Salt 22
Fluralaner Chew Tablets 18
Carprofen 11
Spinosad 9
Maropitant Citrate 9
Fluralaner 5.46% 1-Month Chew 5
Ivermectin 4
Isoflurane 4
Tramadol 4
Pimobendan 4
Oclacitinib Maleate 4
Moxidectin 4
Buprenorphine 4
Mirtazapine 4
Butorphanol 4

Myoclonic jerk Reaction Insights

289 reports name Myoclonic jerk; 23 recorded a death outcome (8.0% of reported events, not a population-level mortality rate). VeDDRA code: 1631.

By species: Dog (271 reports), Cat (16 reports), Human (1 reports). By breed: Terrier - Yorkshire (26), Retriever - Labrador (22), Crossbred Canine/dog (19).

Most co-reported drugs: Sarolaner (52 reports), Afoxolaner (44 reports), Pyrantel Pamoate;Sarolaner (30 reports), Milbemycin Oxime + Spinosad (23 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.