Reaction profile

The FDA adverse-event record for swollen vulva

447 FDA adverse-event reports reference swollen vulva (VeDDRA 825). See the species, breeds, and drugs most associated with it below.

447
reports citing this reaction
8.1%
death-coded share
Dog
most-affected species
Estriol Tablets
most-associated drug
Verify with FDA CVM →
447
Total Reports
36
Deaths
8.1%
Death Rate

Species Most Affected

Dog 417
Cattle 24
Ferret 3
Cat 2
Horse 1

Breeds Most Affected

Crossbred Canine/dog 71
Terrier - Yorkshire 32
Poodle - Miniature 23
Chihuahua 19
Schnauzer - Miniature 16
Terrier - West Highland White 12
Holstein-Friesian also known as Holstein 11
Retriever - Labrador 10
Dog (unknown) 10
Doberman Pinscher 9

Associated Drugs

Estriol Tablets 331
Milbemycin Oxime + Spinosad 14
Oclacitinib Maleate 14
Estriol 5
Progesterone 4
Trilostane 4
Ivermectin 4
Ampicillin Trihydrate 4
Bedinvetmab 4
Spinosad 3
Carprofen 3
Enrofloxacin 3
Lasix 3
Fluralaner 13.64% 12-Week Chew 3
Pyrantel Pamoate;Sarolaner 3
Pyrantel Pamoate/Praziquantel 2
Cephalexin 2
Glycosaminoglycan Polysulfate 2
Propofol 2
Morphine 2

Swollen vulva Reaction Insights

447 reports name Swollen vulva; 36 recorded a death outcome (8.1% of reported events, not a population-level mortality rate). VeDDRA code: 825.

By species: Dog (417 reports), Cattle (24 reports), Ferret (3 reports). By breed: Crossbred Canine/dog (71), Terrier - Yorkshire (32), Poodle - Miniature (23).

Most co-reported drugs: Estriol Tablets (331 reports), Milbemycin Oxime + Spinosad (14 reports), Oclacitinib Maleate (14 reports), Estriol (5 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.