Reaction profile

The FDA adverse-event record for dermal thickening

306 FDA adverse-event reports reference dermal thickening (VeDDRA 930). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#860 of 2,481
by report volume (all reactions)
306
reports citing this reaction
6.9%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Dermal thickening has 306 reports now versus 301 in that prior snapshot: 5 more (1.7%).

Report change
+5
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Dermal thickening changes

FDA AER · VeDDRA plate

Code 930 VOL-LOW

VOL-LOW · DEATH-PAR · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 306 reports
  • DEATH-PAR 6.9%
  • MID-PACK #860/2481
  • PHOTO-FINISH Swollen tongue
  • SPECIES-DOG Dog · 247
  • DRUG-LEAD Oclacitinib Malea… · 42
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Swollen tongue (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Dermal thickening

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Blood in faeces NOS · near307Dermal thickening · this rea…306Swollen tongue · near306Increased bowel movem… · near305Increased seizure fre… · near305Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Dermal thickening

Dermal thickening: low death-coded share in the FDA AER plate

Signature read: Dermal thickening's 6.9% death-coded share is among the lowest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is lower-third: 21 of 306 reports (6.9% of named reports). Nearest volume peer: Swollen tongue (±0 reports). Lead species Dog (247). Lead co-reported drug Oclacitinib Maleate (42).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Oclacitinib Maleate appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 247
Cat 55
Cattle 2
Horse 2

Breeds Most Affected

Retriever - Labrador 43
Domestic Shorthair 35
Shepherd Dog - German 14
Crossbred Canine/dog 12
Terrier - Bull - American Pit 10
Retriever - Golden 9
Domestic Longhair 8
Bulldog - French 8
Boxer (German Boxer) 7
Bulldog 7

Associated Drugs

Oclacitinib Maleate 42
Carprofen 33
Trilostane 29
Prednisone 25
Cefovecin 20
Gabapentin 19
Selamectin 18
Anti-Il31 Mab Mcs Lot #1283563 18
Milbemycin Oxime + Spinosad 17
Maropitant Citrate 17
Moxidectin 17
Afoxolaner 15
Frunevetmab 14
Tigilanol Tiglate 13
Metronidazole 11
Enrofloxacin 11
Isoflurane 10
Cephalexin 10
Cefpodoxime Proxetil 9
Fluralaner Chew Tablets 9

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Dermal thickening, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (6.9% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Dermal thickening (#860 of 2,481 by report volume); death-coded 6.9%. PlainBreed reaction plate · death-coded share stamp 6.9% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →