Reaction profile

The FDA adverse-event record for dermal thickening

289 FDA adverse-event reports reference dermal thickening (VeDDRA 930). See the species, breeds, and drugs most associated with it below.

289
reports citing this reaction
5.9%
death-coded share
Dog
most-affected species
Oclacitinib Maleate
most-associated drug
Verify with FDA CVM →
289
Total Reports
17
Deaths
5.9%
Death Rate

Species Most Affected

Dog 236
Cat 49
Cattle 2
Horse 2

Breeds Most Affected

Retriever - Labrador 41
Domestic Shorthair 32
Shepherd Dog - German 14
Crossbred Canine/dog 12
Retriever - Golden 9
Terrier - Bull - American Pit 9
Bulldog - French 8
Boxer (German Boxer) 7
Bulldog 7
Shih Tzu 7

Associated Drugs

Oclacitinib Maleate 39
Carprofen 31
Trilostane 29
Prednisone 21
Cefovecin 20
Selamectin 18
Milbemycin Oxime + Spinosad 17
Maropitant Citrate 17
Moxidectin 16
Gabapentin 16
Anti-Il31 Mab Mcs Lot #1283563 15
Afoxolaner 14
Tigilanol Tiglate 13
Metronidazole 11
Enrofloxacin 11
Frunevetmab 11
Isoflurane 10
Cephalexin 10
Cefpodoxime Proxetil 9
Fluralaner Chew Tablets 9

Dermal thickening Reaction Insights

289 reports name Dermal thickening; 17 recorded a death outcome (5.9% of reported events, not a population-level mortality rate). VeDDRA code: 930.

By species: Dog (236 reports), Cat (49 reports), Cattle (2 reports). By breed: Retriever - Labrador (41), Domestic Shorthair (32), Shepherd Dog - German (14).

Most co-reported drugs: Oclacitinib Maleate (39 reports), Carprofen (31 reports), Trilostane (29 reports), Prednisone (21 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.