Reaction profile

The FDA adverse-event record for injection site serosanguinous discharge

268 FDA adverse-event reports reference injection site serosanguinous discharge (VeDDRA 104). See the species, breeds, and drugs most associated with it below.

268
reports citing this reaction
7.8%
death-coded share
Dog
most-affected species
Tigilanol Tiglate
most-associated drug
Verify with FDA CVM →
268
Total Reports
21
Deaths
7.8%
Death Rate

Species Most Affected

Dog 255
Horse 4
Cat 4
Cattle 3
Donkey 1
Goat 1

Breeds Most Affected

Retriever - Labrador 35
Pit Bull 28
Boxer (German Boxer) 21
Dog (unknown) 17
Crossbred Canine/dog 11
Beagle 11
Bulldog - French 8
Shepherd Dog - German 6
Chihuahua 6
Pug 6

Associated Drugs

Tigilanol Tiglate 139
Gabapentin 29
Prednisone 29
Melarsomine Dihydrochloride 24
Diphenhydramine 24
Famotidine 23
Carprofen 21
Maropitant Citrate 17
Butorphanol 17
Buprenorphine 15
Dexmedetomidine 15
Propofol 14
Moxidectin 12
Butorphanol Tartrate 12
Hydromorphone 11
Melarsomine Dihydrochloride Injection 10
Atipamezole 10
Bupivacaine Lipsome Injectable Suspension 9
Ketamine 8
Cefovecin 7

Injection site serosanguinous discharge Reaction Insights

268 reports name Injection site serosanguinous discharge; 21 recorded a death outcome (7.8% of reported events, not a population-level mortality rate). VeDDRA code: 104.

By species: Dog (255 reports), Horse (4 reports), Cat (4 reports). By breed: Retriever - Labrador (35), Pit Bull (28), Boxer (German Boxer) (21).

Most co-reported drugs: Tigilanol Tiglate (139 reports), Gabapentin (29 reports), Prednisone (29 reports), Melarsomine Dihydrochloride (24 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.