Reaction profile

The FDA adverse-event record for low serum alkaline phosphatase (alp)

146 FDA adverse-event reports reference low serum alkaline phosphatase (alp) (VeDDRA 2690). See the species, breeds, and drugs most associated with it below.

146
reports citing this reaction
21.2%
death-coded share
Dog
most-affected species
Maropitant Citrate
most-associated drug
Verify with FDA CVM →
146
Total Reports
31
Deaths
21.2%
Death Rate

Species Most Affected

Dog 89
Cat 57

Breeds Most Affected

Domestic Shorthair 30
Retriever - Labrador 18
Crossbred Canine/dog 7
Shepherd Dog - German 7
Domestic Longhair 7
Great Pyrenees 5
Retriever - Golden 5
Domestic Mediumhair 5
Shih Tzu 4
Maine Coon 4

Associated Drugs

Maropitant Citrate 23
Bedinvetmab 18
Afoxolaner 16
Oclacitinib Maleate 13
Eprinomectin + Esafoxolaner + Praziquantel 11
Buprenorphine 10
Metronidazole 9
Fluid Therapy 9
Gabapentin 8
Milbemycin Oxime + Praziquantel 8
Fluralaner 13.64% 12-Week Chew 8
Robenacoxib 7
Velagliflozin Proline Monohydrate 7
Enrofloxacin 7
Rabies Vaccine 7
Pyrantel Pamoate;Sarolaner 6
Bordetella Vaccine 5
Doxycycline 5
Fluralaner 5
Frunevetmab 5

Low serum alkaline phosphatase (ALP) Reaction Insights

146 reports name Low serum alkaline phosphatase (ALP); 31 recorded a death outcome (21.2% of reported events, not a population-level mortality rate). VeDDRA code: 2690.

By species: Dog (89 reports), Cat (57 reports). By breed: Domestic Shorthair (30), Retriever - Labrador (18), Crossbred Canine/dog (7).

Most co-reported drugs: Maropitant Citrate (23 reports), Bedinvetmab (18 reports), Afoxolaner (16 reports), Oclacitinib Maleate (13 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.