Reaction profile

The FDA adverse-event record for low serum alkaline phosphatase (alp)

200 FDA adverse-event reports reference low serum alkaline phosphatase (alp) (VeDDRA 2690). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1033 of 2,481
by report volume (all reactions)
200
reports citing this reaction
16.5%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Low serum alkaline phosphatase (ALP) has 200 reports now versus 172 in that prior snapshot: 28 more (16.3%).

Report change
+28
Death-coded reports
+2
Death-coded share
−1.5 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Low serum alkaline phosphatase (ALP) changes

FDA AER · VeDDRA plate

Code 2690 VOL-LOW

VOL-LOW · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 200 reports
  • DEATH-ELEV 16.5%
  • MID-PACK #1033/2481
  • PHOTO-FINISH PR-SPLEEN, LESION(S)
  • SPECIES-DOG Dog · 115
  • DRUG-LEAD Maropitant Citrate · 39
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: PR-SPLEEN, LESION(S) (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Low serum alkaline phosphatase

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Low serum alkaline ph… · thi…200PR-SPLEEN, LESION(S) · near200Schirmer tear test · near200Anal and rectal disor… · near199Calculi · near199Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Low serum alkaline phosphatase (ALP)

What the FDA AER plate says about Low serum alkaline phosphatase (ALP)

Signature read: 33 death-coded reports is the most distinctive absolute-outcome stamp on Low serum alkaline phosphatase (ALP). Report volume sits in the middle third of the reaction corpus. 33 of 200 reports were death-coded (16.5% of named reports, not a population mortality rate). Nearest volume peer: PR-SPLEEN, LESION(S) (±0 reports). Lead species Dog (115). Lead co-reported drug Maropitant Citrate (39).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Maropitant Citrate appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 115
Cat 83
Horse 2

Breeds Most Affected

Domestic Shorthair 50
Retriever - Labrador 19
Crossbred Canine/dog 10
Shepherd Dog - German 8
Domestic Longhair 7
Domestic Mediumhair 7
Great Pyrenees 5
Retriever - Golden 5
Shih Tzu 5
Maine Coon 4

Associated Drugs

Maropitant Citrate 39
Oclacitinib Maleate 20
Bedinvetmab 20
Gabapentin 17
Buprenorphine 17
Afoxolaner 17
Robenacoxib 16
Metronidazole 14
Fluid Therapy 13
Eprinomectin + Esafoxolaner + Praziquantel 13
Carprofen 9
Milbemycin Oxime + Praziquantel 9
Velagliflozin Proline Monohydrate 8
Rabies Vaccine 8
Fluralaner 13.64% 12-Week Chew 8
Enrofloxacin 7
Frunevetmab 7
Doxycycline 7
Dexmedetomidine 7
Ondansetron 7

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Low serum alkaline phosphatase (ALP), both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (200 here).

Similar death-coded share

Nearest other reactions by death-coded share (16.5% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Low serum alkaline phosphatase (ALP) (#1033 of 2,481 by report volume); death-coded 16.5%. PlainBreed reaction plate · death-coded report count stamp 33 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →