Skin sarcoma NOS

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VeDDRA Code: 921

121 adverse event reports referencing this reaction

121
Total Reports
20
Deaths
1650.0%
Death Rate

Species Most Affected

Dog 111
Cat 10

Breeds Most Affected

Retriever - Labrador 17
Retriever - Golden 8
Crossbred Canine/dog 8
Domestic Shorthair 6
Terrier - Bull - American Pit 6
Boxer (German Boxer) 5
Dog (unknown) 5
Retriever (unspecified) 4
Rottweiler 4
Hound - Basset 4

Associated Drugs

Oclacitinib Maleate 57
Carprofen 10
Bedinvetmab 9
Milbemycin Oxime + Spinosad 8
Anti-Il31 Mab Mcs Lot #1283563 8
Cyclosporine A 7
Trilostane 6
Cyclosporine 5
Gabapentin 5
Moxidectin 4
Afoxolaner 4
Fluralaner 13.64% 12-Week Chew 4
Spinosad 3
Allergy 3
Meloxicam 3
Ivermectin 3
Fluralaner 3
Polysulfated Glycosaminoglycan 3
Fluralaner Chew Tablets 3
Milbemycin Oxime + Praziquantel 3

Data Summary

Metric Value
Total reports referencing reaction 121
Reports with fatal outcome 20
Case-fatality rate (reported events) 1650.0%
Species observed 2
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 921.

Skin sarcoma NOS Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 121 adverse event reports that reference Skin sarcoma NOS as a reaction term, including 20 reports with a death outcome — a 1650.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 921, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Skin sarcoma NOS appears most frequently in reports for Dog (111 reports), Cat (10 reports) — with Dog dominating at 111 entries. Within those species, the breeds most often named alongside this reaction are Retriever - Labrador (17), Retriever - Golden (8), Crossbred Canine/dog (8). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Skin sarcoma NOS are Oclacitinib Maleate (57 reports), Carprofen (10 reports), Bedinvetmab (9 reports), Milbemycin Oxime + Spinosad (8 reports), with Oclacitinib Maleate appearing alongside this reaction in 57 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial