Reaction profile

The FDA adverse-event record for lack of awareness

176 FDA adverse-event reports reference lack of awareness (VeDDRA 1020). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1104 of 2,481
by report volume (all reactions)
176
reports citing this reaction
16.5%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Lack of awareness has 176 reports now versus 173 in that prior snapshot: 3 more (1.7%).

Report change
+3
Death-coded reports
+0
Death-coded share
−0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Lack of awareness changes

FDA AER · VeDDRA plate

Code 1020 VOL-LOW

VOL-LOW · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 176 reports
  • DEATH-ELEV 16.5%
  • MID-PACK #1104/2481
  • PHOTO-FINISH Agonal breathing
  • SPECIES-DOG Dog · 153
  • DRUG-LEAD Milbemycin Oxime… · 31
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Agonal breathing (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Lack of awareness

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Agonal breathing · near176Ear canal disorder · near176Fluid in thorax · near176Gastric distension · near176Lack of awareness · this rea…176Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Lack of awareness

What the FDA AER plate says about Lack of awareness

Signature read: 29 death-coded reports is the most distinctive absolute-outcome stamp on Lack of awareness. Report volume sits in the middle third of the reaction corpus. 29 of 176 reports were death-coded (16.5% of named reports, not a population mortality rate). Nearest volume peer: Agonal breathing (±0 reports). Lead species Dog (153). Lead co-reported drug Milbemycin Oxime + Spinosad (31).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 153
Cat 16
Horse 4
Cattle 1
Other Birds 1
Human 1

Breeds Most Affected

Retriever - Labrador 23
Crossbred Canine/dog 12
Domestic Shorthair 11
Terrier - Yorkshire 8
Chihuahua 7
Retriever - Golden 7
Bulldog 6
Shepherd Dog - Australian 4
Pug 4
Schnauzer - Miniature 4

Associated Drugs

Milbemycin Oxime + Spinosad 31
Afoxolaner 18
Ivermectin + Pyrantel As Pamoate Salt 16
Carprofen 10
Fluralaner Chew Tablets 10
Fluralaner 13.64% 12-Week Chew 10
Bedinvetmab 9
Oclacitinib Maleate 7
Polysulfated Glycosaminoglycan 6
Gabapentin 6
Spinosad 5
Ivermectin 5
Trilostane 5
Nitenpyram 5
Prednisone 4
Cefovecin 4
Buprenorphine 4
Melarsomine Dihydrochloride 4
Maropitant 4
Pyrantel Pamoate;Sarolaner 4

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Lack of awareness, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (176 here).

Similar death-coded share

Nearest other reactions by death-coded share (16.5% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Lack of awareness (#1104 of 2,481 by report volume); death-coded 16.5%. PlainBreed reaction plate · death-coded report count stamp 29 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →