Reaction profile

The FDA adverse-event record for pr-spleen, lesion(s)

198 FDA adverse-event reports reference pr-spleen, lesion(s) (VeDDRA 99679). See the species, breeds, and drugs most associated with it below.

198
reports citing this reaction
89.9%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
198
Total Reports
178
Deaths
89.9%
Death Rate

Species Most Affected

Dog 150
Cattle 23
Cat 21
Horse 3
Pig 1

Breeds Most Affected

Retriever - Labrador 28
Holstein-Friesian also known as Holstein 21
Crossbred Canine/dog 15
Retriever - Golden 13
Domestic (unspecified) 8
Domestic Shorthair 7
Shepherd Dog - Australian 7
Shepherd Dog - German 6
Schnauzer (unspecified) 4
Pug 4

Associated Drugs

Carprofen 40
Maropitant Citrate 15
Florfenicol, Flunixin 14
Spinosad 12
Afoxolaner 11
Fluralaner Chew Tablets 11
Deracoxib 10
Cefovecin Sodium 8
Meloxicam 8
Grapiprant 8
Moxidectin 7
Milbemycin Oxime + Spinosad 7
Tildipirosin 7
Cefovecin 7
Ivermectin + Pyrantel As Pamoate Salt 7
Oclacitinib Maleate 7
Imidacloprid + Moxidectin 6
Enrofloxacin 5
Firocoxib 4
Dexamethasone 4

PR-SPLEEN, LESION(S) Reaction Insights

198 reports name PR-SPLEEN, LESION(S); 178 recorded a death outcome (89.9% of reported events, not a population-level mortality rate). VeDDRA code: 99679.

By species: Dog (150 reports), Cattle (23 reports), Cat (21 reports). By breed: Retriever - Labrador (28), Holstein-Friesian also known as Holstein (21), Crossbred Canine/dog (15).

Most co-reported drugs: Carprofen (40 reports), Maropitant Citrate (15 reports), Florfenicol, Flunixin (14 reports), Spinosad (12 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.