Reaction profile

The FDA adverse-event record for general pain (see other socs for specific pain)

742 FDA adverse-event reports reference general pain (see other socs for specific pain) (VeDDRA 1011). See the species, breeds, and drugs most associated with it below.

742
reports citing this reaction
16.3%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
742
Total Reports
121
Deaths
16.3%
Death Rate

Species Most Affected

Dog 620
Cat 85
Horse 20
Human 14
Sheep 1
Cattle 1
Pig 1

Breeds Most Affected

Retriever - Labrador 63
Domestic Shorthair 54
Crossbred Canine/dog 45
Chihuahua 39
Shepherd Dog - German 23
Boxer (German Boxer) 22
Dog (unknown) 20
Terrier - Yorkshire 20
Beagle 17
Shih Tzu 16

Associated Drugs

Carprofen 78
Moxidectin 54
Fluralaner Chew Tablets 54
Maropitant Citrate 48
Milbemycin Oxime + Spinosad 46
Gabapentin 37
Melarsomine Dihydrochloride 35
Cefovecin 33
Meloxicam 31
Melarsomine Dihydrochloride Injection 29
Selamectin 29
Polysulfated Glycosaminoglycan 27
Prednisone 26
Tramadol 22
Afoxolaner 22
Bedinvetmab 22
Fluralaner 13.64% 12-Week Chew 21
Enrofloxacin 20
Dexamethasone 19
Oclacitinib Maleate 19

General pain (see other SOCs for specific pain) Reaction Insights

742 reports name General pain (see other SOCs for specific pain); 121 recorded a death outcome (16.3% of reported events, not a population-level mortality rate). VeDDRA code: 1011.

By species: Dog (620 reports), Cat (85 reports), Horse (20 reports). By breed: Retriever - Labrador (63), Domestic Shorthair (54), Crossbred Canine/dog (45).

Most co-reported drugs: Carprofen (78 reports), Moxidectin (54 reports), Fluralaner Chew Tablets (54 reports), Maropitant Citrate (48 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.