Reaction profile

The FDA adverse-event record for increased coagulation time

264 FDA adverse-event reports reference increased coagulation time (VeDDRA 2209). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#912 of 2,481
by report volume (all reactions)
264
reports citing this reaction
37.1%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Increased coagulation time has 264 reports now versus 263 in that prior snapshot: 1 more (0.4%).

Report change
+1
Death-coded reports
+1
Death-coded share
+0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Increased coagulation time changes

FDA AER · VeDDRA plate

Code 2209 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 264 reports
  • DEATH-HOT 37.1%
  • MID-PACK #912/2481
  • PHOTO-FINISH Diabetic ketonuria
  • SPECIES-DOG Dog · 247
  • DRUG-LEAD Maropitant Citrate · 70
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Diabetic ketonuria (±1 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Increased coagulation time

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Diabetic ketonuria · near265Injection site warmth · near265Increased coagulation… · thi…264Hyperaemic mucous mem… · near263Impaired vocalisation · near263Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Increased coagulation time

Increased coagulation time: high death-coded share in the FDA AER plate

Signature read: Increased coagulation time's 37.1% death-coded share is among the highest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 98 of 264 reports (37.1% of named reports). Nearest volume peer: Diabetic ketonuria (±1 reports). Lead species Dog (247). Lead co-reported drug Maropitant Citrate (70).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 247
Cat 17

Breeds Most Affected

Retriever - Labrador 41
Retriever - Golden 13
Crossbred Canine/dog 12
Boxer (German Boxer) 10
Terrier - Bull - American Pit 8
Terrier - Jack Russell 8
Domestic Shorthair 8
Terrier (unspecified) 8
Dachshund (unspecified) 7
Rottweiler 7

Associated Drugs

Maropitant Citrate 70
Carprofen 53
Moxidectin 45
Gabapentin 22
Oclacitinib Maleate 21
Diphenhydramine Hcl 20
Enrofloxacin 18
Dexamethasone 17
Tramadol 16
Afoxolaner 15
Plasma 15
Milbemycin Oxime + Spinosad 14
Famotidine 14
Propofol 14
Polysulfated Glycosaminoglycan 13
Sucralfate 13
Dextrose 13
Metronidazole 12
Deracoxib 12
Ampicillin 12

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Increased coagulation time, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (264 here).

Similar death-coded share

Nearest other reactions by death-coded share (37.1% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Increased coagulation time (#912 of 2,481 by report volume); death-coded 37.1%. PlainBreed reaction plate · death-coded share stamp 37.1% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →