Reaction profile

The FDA adverse-event record for increased coagulation time

257 FDA adverse-event reports reference increased coagulation time (VeDDRA 2209). See the species, breeds, and drugs most associated with it below.

257
reports citing this reaction
36.2%
death-coded share
Dog
most-affected species
Maropitant Citrate
most-associated drug
Verify with FDA CVM →
257
Total Reports
93
Deaths
36.2%
Death Rate

Species Most Affected

Dog 241
Cat 16

Breeds Most Affected

Retriever - Labrador 41
Crossbred Canine/dog 12
Retriever - Golden 12
Boxer (German Boxer) 10
Terrier - Jack Russell 8
Terrier (unspecified) 8
Dachshund (unspecified) 7
Rottweiler 7
Terrier - Bull - American Pit 7
Domestic Shorthair 7

Associated Drugs

Maropitant Citrate 68
Carprofen 52
Moxidectin 44
Oclacitinib Maleate 21
Diphenhydramine Hcl 20
Gabapentin 20
Enrofloxacin 18
Dexamethasone 16
Tramadol 16
Afoxolaner 15
Plasma 15
Milbemycin Oxime + Spinosad 14
Famotidine 14
Propofol 14
Polysulfated Glycosaminoglycan 13
Sucralfate 13
Dextrose 13
Ampicillin 12
Deracoxib 12
Metronidazole 11

Increased coagulation time Reaction Insights

257 reports name Increased coagulation time; 93 recorded a death outcome (36.2% of reported events, not a population-level mortality rate). VeDDRA code: 2209.

By species: Dog (241 reports), Cat (16 reports). By breed: Retriever - Labrador (41), Crossbred Canine/dog (12), Retriever - Golden (12).

Most co-reported drugs: Maropitant Citrate (68 reports), Carprofen (52 reports), Moxidectin (44 reports), Oclacitinib Maleate (21 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.