Reaction profile

The FDA adverse-event record for hepato-biliary disorder nos

89 FDA adverse-event reports reference hepato-biliary disorder nos (VeDDRA 2018). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1447 of 2,481
by report volume (all reactions)
89
reports citing this reaction
37.1%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hepato-biliary disorder NOS has 89 reports now versus 89 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hepato-biliary disorder NOS changes

FDA AER · VeDDRA plate

Code 2018 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 89 reports
  • DEATH-HOT 37.1%
  • MID-PACK #1447/2481
  • PHOTO-FINISH Cervical pain
  • SPECIES-DOG Dog · 67
  • DRUG-LEAD Carprofen · 17
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Cervical pain (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Hepato-biliary disorder NOS

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Cervical pain · near89Hepato-biliary disord… · thi…89Injection site self t… · near89Liver nodules · near89Spleen hypertrophy · near89Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Hepato-biliary disorder NOS

Hepato-biliary disorder NOS: high death-coded share in the FDA AER plate

Signature read: Hepato-biliary disorder NOS's 37.1% death-coded share is among the highest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 33 of 89 reports (37.1% of named reports). Nearest volume peer: Cervical pain (±0 reports). Lead species Dog (67). Lead co-reported drug Carprofen (17).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 67
Cat 13
Cattle 4
Horse 3
Human 2

Breeds Most Affected

Retriever - Labrador 8
Domestic Shorthair 5
Spitz - German Pomeranian 4
Shepherd Dog - German 4
Shepherd Dog - Australian 4
Maltese 3
Dog (unknown) 3
Poodle (unspecified) 3
Terrier - Jack Russell 3
Persian 2

Associated Drugs

Carprofen 17
Milbemycin Oxime + Spinosad 10
Maropitant Citrate 10
Oclacitinib Maleate 9
Spinosad 8
Trilostane 5
Gabapentin 5
Afoxolaner 4
Imidacloprid + Moxidectin 3
Famotidine 3
Buprenorphine 3
Fluralaner Chew Tablets 3
Metronidazole 3
Cefovecin 3
Canine Da2Ppv (Orig S-P Us) Lv 3
Canine Lepto*4(Orig S-P Us) Kb 3
Fenbendazol Granules 3
Milbemycin/Lufenuron Tablets 3
Firocoxib 227 Mg Chewable 2
Phenobarbital 2

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Hepato-biliary disorder NOS, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (89 here).

Similar death-coded share

Nearest other reactions by death-coded share (37.1% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hepato-biliary disorder NOS (#1447 of 2,481 by report volume); death-coded 37.1%. PlainBreed reaction plate · death-coded share stamp 37.1% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →