Reaction profile

The FDA adverse-event record for impaired vocalisation

251 FDA adverse-event reports reference impaired vocalisation (VeDDRA 1935). See the species, breeds, and drugs most associated with it below.

251
reports citing this reaction
19.9%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
251
Total Reports
50
Deaths
19.9%
Death Rate

Species Most Affected

Dog 155
Cat 77
Turkey 17
Horse 1
Goat 1

Breeds Most Affected

Domestic Shorthair 40
Turkey (unknown) 16
Retriever - Labrador 13
Crossbred Canine/dog 12
Chihuahua 10
Shepherd Dog - German 9
Domestic Longhair 8
Shih Tzu 7
Domestic Mediumhair 5
Terrier - West Highland White 5

Associated Drugs

Milbemycin Oxime + Spinosad 26
Monensin Sodium 17
Bedinvetmab 17
Afoxolaner 16
Imidacloprid + Moxidectin 15
Maropitant Citrate 12
Pyrantel Pamoate;Sarolaner 12
Selamectin 11
Prednisone 10
Buprenorphine 9
Fluralaner 13.64% 12-Week Chew 9
Spinosad 8
Nitenpyram 8
Fluralaner Chew Tablets 8
Gabapentin 8
Carprofen 7
Moxidectin 7
Cefovecin 7
Frunevetmab 7
Cyclosporine A 6

Impaired vocalisation Reaction Insights

251 reports name Impaired vocalisation; 50 recorded a death outcome (19.9% of reported events, not a population-level mortality rate). VeDDRA code: 1935.

By species: Dog (155 reports), Cat (77 reports), Turkey (17 reports). By breed: Domestic Shorthair (40), Turkey (unknown) (16), Retriever - Labrador (13).

Most co-reported drugs: Milbemycin Oxime + Spinosad (26 reports), Monensin Sodium (17 reports), Bedinvetmab (17 reports), Afoxolaner (16 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.