Reaction profile

The FDA adverse-event record for chronic renal failure

247 FDA adverse-event reports reference chronic renal failure (VeDDRA 1160). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#943 of 2,481
by report volume (all reactions)
247
reports citing this reaction
37.2%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Chronic renal failure has 247 reports now versus 247 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Chronic renal failure changes

FDA AER · VeDDRA plate

Code 1160 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 247 reports
  • DEATH-HOT 37.2%
  • MID-PACK #943/2481
  • PHOTO-FINISH INEFFECTIVE, ESTRUS S…
  • SPECIES-DOG Dog · 165
  • DRUG-LEAD Fluralaner Chew T… · 21
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: INEFFECTIVE, ESTRUS SYNCHRONIZ (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Chronic renal failure

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Increased sensitivity… · near248INEFFECTIVE, REVERSAL · near248Chronic renal failure · this…247INEFFECTIVE, ESTRUS S… · near247Locomotor disturbance · near246Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Chronic renal failure

Chronic renal failure: high death-coded share in the FDA AER plate

Signature read: Chronic renal failure's 37.2% death-coded share is among the highest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 92 of 247 reports (37.2% of named reports). Nearest volume peer: INEFFECTIVE, ESTRUS SYNCHRONIZ (±0 reports). Lead species Dog (165). Lead co-reported drug Fluralaner Chew Tablets (21).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 165
Cat 75
Horse 6
Gerbil 1

Breeds Most Affected

Domestic Shorthair 50
Crossbred Canine/dog 16
Retriever - Labrador 13
Shih Tzu 12
Terrier - Yorkshire 9
Domestic Longhair 7
Retriever - Golden 6
Dog (unknown) 6
Chihuahua 6
Collie - Border 6

Associated Drugs

Fluralaner Chew Tablets 21
Trilostane 19
Milbemycin Oxime + Spinosad 18
Spinosad 17
Frunevetmab 16
Bedinvetmab 16
Polysulfated Glycosaminoglycan 14
Meloxicam 13
Carprofen 12
Grapiprant 11
Deracoxib 10
Maropitant Citrate 10
Gabapentin 10
Prednisone 8
Ivermectin + Pyrantel As Pamoate Salt 8
Afoxolaner 7
Desoxycorticosterone Pivalate 6
Fluralaner 13.64% 12-Week Chew 6
Methimazole 6
Pimobendan 5

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Chronic renal failure, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (37.2% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Chronic renal failure (#943 of 2,481 by report volume); death-coded 37.2%. PlainBreed reaction plate · death-coded share stamp 37.2% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →