Reaction profile

The FDA adverse-event record for diabetic ketonuria

265 FDA adverse-event reports reference diabetic ketonuria (VeDDRA 2054). See the species, breeds, and drugs most associated with it below.

265
reports citing this reaction
28.3%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
265
Total Reports
75
Deaths
28.3%
Death Rate

Species Most Affected

Dog 209
Cat 56

Breeds Most Affected

Domestic Shorthair 28
Crossbred Canine/dog 25
Retriever - Labrador 21
Chihuahua 12
Terrier - Yorkshire 11
Shih Tzu 11
Maltese 9
Domestic (unspecified) 8
Terrier (unspecified) 8
Domestic Longhair 7

Associated Drugs

Trilostane 79
Insulin Injectable Vial 31
Insulin 23
Carprofen 19
Bexagliflozin 18
Milbemycin Oxime + Spinosad 17
Maropitant Citrate 16
Recombinant Human Insulin 16
Famotidine 12
Cyclosporine 10
Moxidectin 9
Prednisone 9
Oclacitinib Maleate 8
Velagliflozin Proline Monohydrate 8
Gabapentin 7
Spinosad 6
Cefovecin 6
Buprenorphine 6
Methylprednisolone Acetate 5
Porcine Insulin 5

Diabetic ketonuria Reaction Insights

265 reports name Diabetic ketonuria; 75 recorded a death outcome (28.3% of reported events, not a population-level mortality rate). VeDDRA code: 2054.

By species: Dog (209 reports), Cat (56 reports). By breed: Domestic Shorthair (28), Crossbred Canine/dog (25), Retriever - Labrador (21).

Most co-reported drugs: Trilostane (79 reports), Insulin Injectable Vial (31 reports), Insulin (23 reports), Carprofen (19 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.