Enlarged liver
VeDDRA Code: 495
588 adverse event reports referencing this reaction
588
Total Reports
220
Deaths
3740.0%
Death Rate
Species Most Affected
Dog 524
Cat 50
Cattle 4
Horse 3
Pig 3
Other Birds 2
Chicken 1
Human 1
Breeds Most Affected
Retriever - Labrador 71
Domestic Shorthair 34
Crossbred Canine/dog 31
Terrier - Yorkshire 24
Beagle 20
Chihuahua 19
Retriever - Golden 19
Maltese 17
Shih Tzu 12
Terrier (unspecified) 12
Associated Drugs
Trilostane 96
Carprofen 83
Milbemycin Oxime + Spinosad 61
Maropitant Citrate 60
Bedinvetmab 45
Oclacitinib Maleate 40
Gabapentin 37
Fluralaner Chew Tablets 35
Prednisone 30
Enrofloxacin 27
Afoxolaner 26
Tramadol 24
Grapiprant 22
Cefovecin 20
Doxycycline 18
Spinosad 17
Metronidazole 17
Moxidectin 16
Buprenorphine 16
Cyclosporine 15
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.