Reaction profile

The FDA adverse-event record for pyelonephritis

126 FDA adverse-event reports reference pyelonephritis (VeDDRA 716). See the species, breeds, and drugs most associated with it below.

126
reports citing this reaction
34.1%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
126
Total Reports
43
Deaths
34.1%
Death Rate

Species Most Affected

Dog 83
Cat 40
Horse 2
Cattle 1

Breeds Most Affected

Domestic Shorthair 24
Retriever - Labrador 8
Crossbred Canine/dog 6
Domestic Longhair 5
Beagle 4
Shih Tzu 4
Terrier (unspecified) 3
Terrier - Boston 3
Terrier - Yorkshire 3
Cat (unknown) 3

Associated Drugs

Trilostane 18
Maropitant Citrate 16
Carprofen 13
Milbemycin Oxime + Spinosad 11
Bedinvetmab 11
Oclacitinib Maleate 10
Enrofloxacin 9
Gabapentin 8
Cefovecin 7
Furosemide 7
Buprenorphine 6
Afoxolaner 5
Meloxicam 5
Pimobendan 5
Cyclosporine 5
Prednisone 5
Pradofloxacin 4
Anti-Il31 Mab Mcs Lot #1283563 4
Polysulfated Glycosaminoglycan 4
Metronidazole 4

Pyelonephritis Reaction Insights

126 reports name Pyelonephritis; 43 recorded a death outcome (34.1% of reported events, not a population-level mortality rate). VeDDRA code: 716.

By species: Dog (83 reports), Cat (40 reports), Horse (2 reports). By breed: Domestic Shorthair (24), Retriever - Labrador (8), Crossbred Canine/dog (6).

Most co-reported drugs: Trilostane (18 reports), Maropitant Citrate (16 reports), Carprofen (13 reports), Milbemycin Oxime + Spinosad (11 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.