Inappropriate elimination NOS

Verify with FDA CVM →

VeDDRA Code: 2674

222 adverse event reports referencing this reaction

222
Total Reports
63
Deaths
2840.0%
Death Rate

Species Most Affected

Dog 173
Cat 48
Rabbit 1

Breeds Most Affected

Domestic Shorthair 34
Retriever - Labrador 15
Dog (unknown) 15
Shepherd Dog - German 11
Crossbred Canine/dog 8
Retriever - Golden 7
Terrier - Boston 6
Domestic Longhair 5
Spaniel (unspecified) 5
Beagle 5

Associated Drugs

Bedinvetmab 81
Gabapentin 29
Pyrantel Pamoate;Sarolaner 23
Carprofen 19
Trilostane 18
Maropitant Citrate 16
Frunevetmab 14
Sarolaner 9
Cefovecin 8
Afoxolaner 7
Prednisone 7
Enrofloxacin 6
Grapiprant 6
Selamectin;Sarolaner 5
Moxidectin 5
Anti-Il31 Mab Mcs Lot #1283563 5
Diphenhydramine 5
Galliprant 5
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 5
Ivermectin + Pyrantel As Pamoate Salt 4

Data Summary

Metric Value
Total reports referencing reaction 222
Reports with fatal outcome 63
Case-fatality rate (reported events) 2840.0%
Species observed 3
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 2674.

Inappropriate elimination NOS Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 222 adverse event reports that reference Inappropriate elimination NOS as a reaction term, including 63 reports with a death outcome — a 2840.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 2674, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Inappropriate elimination NOS appears most frequently in reports for Dog (173 reports), Cat (48 reports), Rabbit (1 reports) — with Dog dominating at 173 entries. Within those species, the breeds most often named alongside this reaction are Domestic Shorthair (34), Retriever - Labrador (15), Dog (unknown) (15). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Inappropriate elimination NOS are Bedinvetmab (81 reports), Gabapentin (29 reports), Pyrantel Pamoate;Sarolaner (23 reports), Carprofen (19 reports), with Bedinvetmab appearing alongside this reaction in 81 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial