Reaction profile

The FDA adverse-event record for breathlessness

118 FDA adverse-event reports reference breathlessness (VeDDRA 1915). See the species, breeds, and drugs most associated with it below.

118
reports citing this reaction
27.1%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
118
Total Reports
32
Deaths
27.1%
Death Rate

Species Most Affected

Dog 88
Human 17
Cat 12
Pig 1

Breeds Most Affected

Unknown 18
Crossbred Canine/dog 7
Chihuahua 6
Retriever - Labrador 6
Terrier - Yorkshire 6
Domestic Shorthair 6
Pug 4
Boxer (German Boxer) 4
Beagle 3
Shepherd Dog - German 3

Associated Drugs

Milbemycin Oxime + Spinosad 22
Buprenorphine 8
Afoxolaner 7
Spinosad 6
Isoflurane 6
Bedinvetmab 6
Fluralaner 13.64% 12-Week Chew 5
Maropitant Citrate 4
Nitenpyram 4
Fluralaner Chew Tablets 4
Ivermectin + Pyrantel As Pamoate Salt 4
Afoxolaner 136 Mg Chewable Tablets 4
Butorphanol 4
Ketamine 4
Propofol 4
Dexmedetomidine 4
Trilostane 4
Tilmicosin Phosphate 3
Carprofen 3
Selamectin 3

Breathlessness Reaction Insights

118 reports name Breathlessness; 32 recorded a death outcome (27.1% of reported events, not a population-level mortality rate). VeDDRA code: 1915.

By species: Dog (88 reports), Human (17 reports), Cat (12 reports). By breed: Unknown (18), Crossbred Canine/dog (7), Chihuahua (6).

Most co-reported drugs: Milbemycin Oxime + Spinosad (22 reports), Buprenorphine (8 reports), Afoxolaner (7 reports), Spinosad (6 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.