Reaction profile

The FDA adverse-event record for cardiorespiratory arrest

237 FDA adverse-event reports reference cardiorespiratory arrest (VeDDRA 219). See the species, breeds, and drugs most associated with it below.

237
reports citing this reaction
86.9%
death-coded share
Dog
most-affected species
Maropitant Citrate
most-associated drug
Verify with FDA CVM →
237
Total Reports
206
Deaths
86.9%
Death Rate

Species Most Affected

Dog 163
Cat 70
Guinea Pig 2
Jaguar 1
Horse 1

Breeds Most Affected

Domestic Shorthair 39
Shih Tzu 16
Retriever - Labrador 11
Shepherd Dog - German 10
Chihuahua 9
Domestic Mediumhair 8
Bulldog - French 8
Pug 7
Shar Pei 6
Terrier - Yorkshire 5

Associated Drugs

Maropitant Citrate 43
Isoflurane 35
Carprofen 35
Butorphanol 30
Dexmedetomidine Hydrochloride 27
Propofol 25
Buprenorphine 24
Ketamine 20
Atipamezole Hydrochloride 18
Alfaxalone 18
Moxidectin 16
Cefovecin 15
Dexmedetomidine 14
Ketamine Hydrochloride 13
Acepromazine Maleate 12
Butorphanol Tartrate 12
Meloxicam 11
Atropine 10
Epinephrine 10
Tigilanol Tiglate 10

Cardiorespiratory arrest Reaction Insights

237 reports name Cardiorespiratory arrest; 206 recorded a death outcome (86.9% of reported events, not a population-level mortality rate). VeDDRA code: 219.

By species: Dog (163 reports), Cat (70 reports), Guinea Pig (2 reports). By breed: Domestic Shorthair (39), Shih Tzu (16), Retriever - Labrador (11).

Most co-reported drugs: Maropitant Citrate (43 reports), Isoflurane (35 reports), Carprofen (35 reports), Butorphanol (30 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.