Reaction profile

The FDA adverse-event record for hypoproteinaemia

2,118 FDA adverse-event reports reference hypoproteinaemia (VeDDRA 1976). See the species, breeds, and drugs most associated with it below.

2,118
reports citing this reaction
31.9%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
2,118
Total Reports
675
Deaths
31.9%
Death Rate

Species Most Affected

Dog 1,866
Cat 192
Horse 43
Cattle 7
Sheep 3
Other Canids 3
Pig 1
Human 1
Donkey 1
Monkey 1

Breeds Most Affected

Retriever - Labrador 281
Crossbred Canine/dog 128
Domestic Shorthair 93
Retriever - Golden 92
Terrier - Yorkshire 83
Chihuahua 58
Shepherd Dog - German 54
Shih Tzu 54
Rottweiler 48
Maltese 44

Associated Drugs

Carprofen 352
Maropitant Citrate 263
Oclacitinib Maleate 187
Milbemycin Oxime + Spinosad 178
Afoxolaner 122
Deracoxib 121
Meloxicam 104
Metronidazole 95
Moxidectin 93
Famotidine 87
Fluralaner Chew Tablets 75
Gabapentin 74
Buprenorphine 73
Spinosad 69
Sucralfate 69
Prednisone 66
Cefovecin 66
Enrofloxacin 65
Grapiprant 64
Tramadol 60

Hypoproteinaemia Reaction Insights

2,118 reports name Hypoproteinaemia; 675 recorded a death outcome (31.9% of reported events, not a population-level mortality rate). VeDDRA code: 1976.

By species: Dog (1,866 reports), Cat (192 reports), Horse (43 reports). By breed: Retriever - Labrador (281), Crossbred Canine/dog (128), Domestic Shorthair (93).

Most co-reported drugs: Carprofen (352 reports), Maropitant Citrate (263 reports), Oclacitinib Maleate (187 reports), Milbemycin Oxime + Spinosad (178 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.