Reaction profile

The FDA adverse-event record for hypoproteinaemia

2,220 FDA reports name hypoproteinaemia, a high-volume reaction in the CVM extract (VeDDRA 1976). Plate stamps and neighbourhood peers follow.

#211 of 2,481
by report volume (all reactions)
2,220
reports citing this reaction
32.0%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hypoproteinaemia has 2,220 reports now versus 2,171 in that prior snapshot: 49 more (2.3%).

Report change
+49
Death-coded reports
+13
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hypoproteinaemia changes

FDA AER · VeDDRA plate

Code 1976 VOL-MID

VOL-MID · DEATH-HOT · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 2,220 reports
  • DEATH-HOT 32.0%
  • TOP-DECILE #211/2481
  • PHOTO-FINISH Gagging
  • SPECIES-DOG Dog · 1,951
  • DRUG-LEAD Carprofen · 360
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Gagging (±12 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Hypoproteinaemia

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Caps, Abnormal · near2242Renal failure · near2240Elevated globulins · near2235Hypoproteinaemia · this reac…2220Gagging · near2208Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Hypoproteinaemia

Hypoproteinaemia: high death-coded share in the FDA AER plate

Signature read: 710 death-coded reports is a heavy tail count for Hypoproteinaemia in the CVM extract. Report volume is upper-third scale: 2,220 named reports in the openFDA extract. Death-coded share is upper-third: 710 of 2,220 reports (32.0% of named reports). Nearest volume peer: Gagging (±12 reports). Lead species Dog (1,951). Lead co-reported drug Carprofen (360).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 1,951
Cat 204
Horse 48
Cattle 7
Sheep 3
Other Canids 3
Pig 1
Human 1
Donkey 1
Monkey 1

Breeds Most Affected

Retriever - Labrador 292
Crossbred Canine/dog 135
Domestic Shorthair 103
Retriever - Golden 94
Terrier - Yorkshire 84
Shepherd Dog - German 62
Chihuahua 62
Shih Tzu 55
Rottweiler 48
Dachshund (unspecified) 45

Associated Drugs

Carprofen 360
Maropitant Citrate 296
Oclacitinib Maleate 202
Milbemycin Oxime + Spinosad 178
Afoxolaner 126
Deracoxib 121
Metronidazole 108
Meloxicam 107
Moxidectin 103
Famotidine 92
Gabapentin 90
Buprenorphine 80
Prednisone 76
Fluralaner Chew Tablets 75
Sucralfate 72
Cefovecin 70
Spinosad 69
Enrofloxacin 69
Grapiprant 65
Tramadol 60

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Hypoproteinaemia, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (2,220 here).

Similar death-coded share

Nearest other reactions by death-coded share (32.0% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hypoproteinaemia (#211 of 2,481 by report volume); death-coded 32.0%. PlainBreed reaction plate · death-coded report count stamp 710 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →