Reaction profile

The FDA adverse-event record for gagging

2,208 FDA reports name gagging, a high-volume reaction in the CVM extract (VeDDRA 344). Plate stamps and neighbourhood peers follow.

#212 of 2,481
by report volume (all reactions)
2,208
reports citing this reaction
9.9%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Gagging has 2,208 reports now versus 2,180 in that prior snapshot: 28 more (1.3%).

Report change
+28
Death-coded reports
+4
Death-coded share
+0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Gagging changes

FDA AER · VeDDRA plate

Code 344 VOL-MID

VOL-MID · DEATH-PAR · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 2,208 reports
  • DEATH-PAR 9.9%
  • TOP-DECILE #212/2481
  • PHOTO-FINISH Hypoproteinaemia
  • SPECIES-DOG Dog · 1,740
  • DRUG-LEAD Milbemycin Oxime… · 319
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Hypoproteinaemia (±12 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Gagging

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Elevated globulins · near2235Hypoproteinaemia · near2220Gagging · this reaction2208Ear infection NOS · near2187Lack of efficacy (ect… · near2183Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Gagging

What the FDA AER plate says about Gagging

Signature read: 2,208 reports place Gagging in the upper third of FDA AER volume (#212 of 2,481). Report volume is upper-third scale: 2,208 named reports in the openFDA extract. 219 of 2,208 reports were death-coded (9.9% of named reports, not a population mortality rate). Nearest volume peer: Hypoproteinaemia (±12 reports). Lead species Dog (1,740). Lead co-reported drug Milbemycin Oxime + Spinosad (319).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 1,740
Cat 441
Human 13
Horse 8
Unknown 2
Ferret 2
Other 1
Other Canids 1

Breeds Most Affected

Domestic Shorthair 242
Retriever - Labrador 169
Crossbred Canine/dog 125
Chihuahua 122
Retriever - Golden 72
Shih Tzu 70
Dog (unknown) 66
Terrier - Yorkshire 65
Boxer (German Boxer) 60
Shepherd Dog - German 49

Associated Drugs

Milbemycin Oxime + Spinosad 319
Afoxolaner 148
Ivermectin + Pyrantel As Pamoate Salt 128
Spinosad 104
Maropitant Citrate 97
Pyrantel Pamoate;Sarolaner 88
Milbemycin Oxime + Praziquantel 82
Fluralaner Chew Tablets 80
Imidacloprid + Moxidectin 68
Cyclosporine 65
Fluralaner 13.64% 12-Week Chew 63
Selamectin 60
Oclacitinib Maleate 60
Moxidectin 56
Carprofen 53
Pyrantel Pamoate 50
Nitenpyram 50
Bedinvetmab 48
Prednisone 45
Pimobendan 39

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Gagging, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (9.9% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Gagging (#212 of 2,481 by report volume); death-coded 9.9%. PlainBreed reaction plate · report volume stamp 2,208 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →