Reaction profile

The FDA adverse-event record for gagging

2,144 FDA adverse-event reports reference gagging (VeDDRA 344). See the species, breeds, and drugs most associated with it below.

2,144
reports citing this reaction
9.8%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
2,144
Total Reports
211
Deaths
9.8%
Death Rate

Species Most Affected

Dog 1,686
Cat 431
Human 13
Horse 8
Unknown 2
Ferret 2
Other 1
Other Canids 1

Breeds Most Affected

Domestic Shorthair 237
Retriever - Labrador 162
Crossbred Canine/dog 122
Chihuahua 120
Shih Tzu 68
Retriever - Golden 67
Terrier - Yorkshire 64
Dog (unknown) 64
Boxer (German Boxer) 60
Shepherd Dog - German 49

Associated Drugs

Milbemycin Oxime + Spinosad 319
Afoxolaner 145
Ivermectin + Pyrantel As Pamoate Salt 124
Spinosad 104
Maropitant Citrate 86
Milbemycin Oxime + Praziquantel 82
Pyrantel Pamoate;Sarolaner 81
Fluralaner Chew Tablets 80
Imidacloprid + Moxidectin 68
Cyclosporine 63
Fluralaner 13.64% 12-Week Chew 62
Selamectin 60
Moxidectin 56
Pyrantel Pamoate 50
Oclacitinib Maleate 50
Carprofen 49
Nitenpyram 48
Bedinvetmab 45
Prednisone 42
Pimobendan 39

Gagging Reaction Insights

2,144 reports name Gagging; 211 recorded a death outcome (9.8% of reported events, not a population-level mortality rate). VeDDRA code: 344.

By species: Dog (1,686 reports), Cat (431 reports), Human (13 reports). By breed: Domestic Shorthair (237), Retriever - Labrador (162), Crossbred Canine/dog (122).

Most co-reported drugs: Milbemycin Oxime + Spinosad (319 reports), Afoxolaner (145 reports), Ivermectin + Pyrantel As Pamoate Salt (124 reports), Spinosad (104 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.