Reaction profile

The FDA adverse-event record for elevated globulins

2,031 FDA adverse-event reports reference elevated globulins (VeDDRA 2556). See the species, breeds, and drugs most associated with it below.

2,031
reports citing this reaction
22.9%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
2,031
Total Reports
466
Deaths
22.9%
Death Rate

Species Most Affected

Dog 1,436
Cat 575
Horse 16
Cattle 3
Mouse 1

Breeds Most Affected

Domestic Shorthair 338
Retriever - Labrador 164
Crossbred Canine/dog 131
Boxer (German Boxer) 60
Retriever - Golden 59
Shepherd Dog - German 55
Shih Tzu 54
Chihuahua 52
Domestic Longhair 51
Domestic Mediumhair 42

Associated Drugs

Carprofen 170
Maropitant Citrate 167
Bedinvetmab 161
Gabapentin 126
Oclacitinib Maleate 125
Fluralaner Chew Tablets 114
Cefovecin 106
Afoxolaner 103
Moxidectin 101
Trilostane 80
Meloxicam 73
Velagliflozin Proline Monohydrate 72
Buprenorphine 70
Prednisone 62
Milbemycin Oxime + Spinosad 59
Ivermectin + Pyrantel As Pamoate Salt 58
Robenacoxib 53
Doxycycline 52
Milbemycin Oxime + Praziquantel 51
Enrofloxacin 49

Elevated globulins Reaction Insights

2,031 reports name Elevated globulins; 466 recorded a death outcome (22.9% of reported events, not a population-level mortality rate). VeDDRA code: 2556.

By species: Dog (1,436 reports), Cat (575 reports), Horse (16 reports). By breed: Domestic Shorthair (338), Retriever - Labrador (164), Crossbred Canine/dog (131).

Most co-reported drugs: Carprofen (170 reports), Maropitant Citrate (167 reports), Bedinvetmab (161 reports), Gabapentin (126 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.