Oedema NOS (see other SOCs for specific oedemas)

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VeDDRA Code: 1029

509 adverse event reports referencing this reaction

509
Total Reports
160
Deaths
3140.0%
Death Rate

Species Most Affected

Dog 382
Cat 52
Horse 46
Cattle 15
Human 10
Pig 2
Goat 2

Breeds Most Affected

Retriever - Labrador 48
Crossbred Canine/dog 39
Retriever - Golden 21
Domestic Shorthair 19
Boxer (German Boxer) 18
Shepherd Dog - German 14
Chihuahua 14
Dog (unknown) 13
Pit Bull 12
Rottweiler 12

Associated Drugs

Carprofen 89
Maropitant Citrate 43
Moxidectin 26
Oclacitinib Maleate 26
Prednisone 25
Deracoxib 24
Milbemycin Oxime + Spinosad 24
Gabapentin 23
Buprenorphine 18
Meloxicam 17
Butorphanol 17
Maropitant 16
Tramadol 16
Afoxolaner 16
Bedinvetmab 16
Firocoxib 15
Enrofloxacin 15
Polysulfated Glycosaminoglycan 15
Famotidine 15
Tigilanol Tiglate 15

Data Summary

Metric Value
Total reports referencing reaction 509
Reports with fatal outcome 160
Case-fatality rate (reported events) 3140.0%
Species observed 7
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 1029.

Oedema NOS (see other SOCs for specific oedemas) Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 509 adverse event reports that reference Oedema NOS (see other SOCs for specific oedemas) as a reaction term, including 160 reports with a death outcome — a 3140.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 1029, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Oedema NOS (see other SOCs for specific oedemas) appears most frequently in reports for Dog (382 reports), Cat (52 reports), Horse (46 reports) — with Dog dominating at 382 entries. Within those species, the breeds most often named alongside this reaction are Retriever - Labrador (48), Crossbred Canine/dog (39), Retriever - Golden (21). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Oedema NOS (see other SOCs for specific oedemas) are Carprofen (89 reports), Maropitant Citrate (43 reports), Moxidectin (26 reports), Oclacitinib Maleate (26 reports), with Carprofen appearing alongside this reaction in 89 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial