Reaction profile

The FDA adverse-event record for oedema nos (see other socs for specific oedemas)

529 FDA reports name oedema nos (see other socs for specific oedemas), a high-volume reaction in the CVM extract (VeDDRA 1029). Plate stamps and neighbourhood peers follow.

#624 of 2,481
by report volume (all reactions)
529
reports citing this reaction
31.9%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Oedema NOS (see other SOCs for specific oedemas) has 529 reports now versus 519 in that prior snapshot: 10 more (1.9%).

Report change
+10
Death-coded reports
+3
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Oedema NOS (see other SOCs for specific oedemas) changes

FDA AER · VeDDRA plate

Code 1029 VOL-MID

VOL-MID · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 529 reports
  • DEATH-HOT 31.9%
  • MID-PACK #624/2481
  • PHOTO-FINISH Rectal bleeding
  • SPECIES-DOG Dog · 396
  • DRUG-LEAD Carprofen · 90
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Rectal bleeding (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Oedema NOS

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Application site crust · near530Loss of consciousness · near530Oedema NOS (see other… · thi…529Rectal bleeding · near529Lot # and /or Expirat… · near528Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Oedema NOS (see other SOCs for specific oedemas)

Oedema NOS (see other SOCs for specific oedemas): high death-coded share in the FDA AER plate

Signature read: 169 death-coded reports is a heavy tail count for Oedema NOS (see other SOCs for specific oedemas) in the CVM extract. Report volume is upper-third scale: 529 named reports in the openFDA extract. Death-coded share is upper-third: 169 of 529 reports (31.9% of named reports). Nearest volume peer: Rectal bleeding (±0 reports). Lead species Dog (396). Lead co-reported drug Carprofen (90).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 396
Cat 55
Horse 48
Cattle 16
Human 10
Pig 2
Goat 2

Breeds Most Affected

Retriever - Labrador 49
Crossbred Canine/dog 40
Domestic Shorthair 22
Retriever - Golden 21
Boxer (German Boxer) 19
Chihuahua 15
Shepherd Dog - German 14
Dog (unknown) 13
Pit Bull 12
Rottweiler 12

Associated Drugs

Carprofen 90
Maropitant Citrate 47
Oclacitinib Maleate 29
Moxidectin 27
Gabapentin 27
Prednisone 26
Deracoxib 24
Milbemycin Oxime + Spinosad 24
Butorphanol 20
Buprenorphine 18
Meloxicam 17
Afoxolaner 17
Bedinvetmab 17
Maropitant 16
Polysulfated Glycosaminoglycan 16
Isoflurane 16
Tramadol 16
Firocoxib 15
Enrofloxacin 15
Doxycycline 15

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Oedema NOS (see other SOCs for specific oedemas), both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (31.9% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Oedema NOS (see other SOCs for specific oedemas) (#624 of 2,481 by report volume); death-coded 31.9%. PlainBreed reaction plate · death-coded report count stamp 169 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →