Reaction profile

The FDA adverse-event record for oedema nos (see other socs for specific oedemas)

509 FDA adverse-event reports reference oedema nos (see other socs for specific oedemas) (VeDDRA 1029). See the species, breeds, and drugs most associated with it below.

509
reports citing this reaction
31.4%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
509
Total Reports
160
Deaths
31.4%
Death Rate

Species Most Affected

Dog 382
Cat 52
Horse 46
Cattle 15
Human 10
Pig 2
Goat 2

Breeds Most Affected

Retriever - Labrador 48
Crossbred Canine/dog 39
Retriever - Golden 21
Domestic Shorthair 19
Boxer (German Boxer) 18
Shepherd Dog - German 14
Chihuahua 14
Dog (unknown) 13
Pit Bull 12
Rottweiler 12

Associated Drugs

Carprofen 89
Maropitant Citrate 43
Moxidectin 26
Oclacitinib Maleate 26
Prednisone 25
Deracoxib 24
Milbemycin Oxime + Spinosad 24
Gabapentin 23
Buprenorphine 18
Meloxicam 17
Butorphanol 17
Maropitant 16
Tramadol 16
Afoxolaner 16
Bedinvetmab 16
Firocoxib 15
Enrofloxacin 15
Polysulfated Glycosaminoglycan 15
Famotidine 15
Tigilanol Tiglate 15

Oedema NOS (see other SOCs for specific oedemas) Reaction Insights

509 reports name Oedema NOS (see other SOCs for specific oedemas); 160 recorded a death outcome (31.4% of reported events, not a population-level mortality rate). VeDDRA code: 1029.

By species: Dog (382 reports), Cat (52 reports), Horse (46 reports). By breed: Retriever - Labrador (48), Crossbred Canine/dog (39), Retriever - Golden (21).

Most co-reported drugs: Carprofen (89 reports), Maropitant Citrate (43 reports), Moxidectin (26 reports), Oclacitinib Maleate (26 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.