Reaction profile

The FDA adverse-event record for decreased packed cell volume (pcv)

1,741 FDA adverse-event reports reference decreased packed cell volume (pcv) (VeDDRA 2215). See the species, breeds, and drugs most associated with it below.

1,741
reports citing this reaction
32.2%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
1,741
Total Reports
561
Deaths
32.2%
Death Rate

Species Most Affected

Dog 1,353
Cat 367
Horse 17
Rabbit 2
Ferret 1
Sheep 1

Breeds Most Affected

Domestic Shorthair 236
Retriever - Labrador 181
Crossbred Canine/dog 132
Retriever - Golden 68
Shih Tzu 55
Chihuahua 52
Shepherd Dog - German 38
Domestic Longhair 38
Beagle 35
Maltese 32

Associated Drugs

Carprofen 168
Fluralaner Chew Tablets 161
Trilostane 148
Maropitant Citrate 147
Prednisone 137
Oclacitinib Maleate 136
Cefovecin 102
Gabapentin 77
Afoxolaner 76
Moxidectin 70
Meloxicam 69
Doxycycline 64
Dexamethasone 61
Ivermectin + Pyrantel As Pamoate Salt 58
Famotidine 58
Buprenorphine 56
Fluralaner 13.64% 12-Week Chew 53
Enrofloxacin 49
Polysulfated Glycosaminoglycan 48
Tramadol 46

Decreased packed cell volume (PCV) Reaction Insights

1,741 reports name Decreased packed cell volume (PCV); 561 recorded a death outcome (32.2% of reported events, not a population-level mortality rate). VeDDRA code: 2215.

By species: Dog (1,353 reports), Cat (367 reports), Horse (17 reports). By breed: Domestic Shorthair (236), Retriever - Labrador (181), Crossbred Canine/dog (132).

Most co-reported drugs: Carprofen (168 reports), Fluralaner Chew Tablets (161 reports), Trilostane (148 reports), Maropitant Citrate (147 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.