Reaction profile

The FDA adverse-event record for renal failure

2,160 FDA adverse-event reports reference renal failure (VeDDRA 720). See the species, breeds, and drugs most associated with it below.

2,160
reports citing this reaction
56.1%
death-coded share
Dog
most-affected species
Meloxicam
most-associated drug
Verify with FDA CVM →
2,160
Total Reports
1,211
Deaths
56.1%
Death Rate

Species Most Affected

Dog 1,545
Cat 584
Horse 16
Goat 5
Human 2
Cattle 2
Ferret 1
Pig 1
Parrot 1
Unknown 1

Breeds Most Affected

Domestic Shorthair 206
Domestic (unspecified) 152
Retriever - Labrador 151
Dog (unknown) 116
Crossbred Canine/dog 114
Terrier - Yorkshire 87
Cat (unknown) 71
Chihuahua 67
Retriever - Golden 59
Shepherd Dog - German 45

Associated Drugs

Meloxicam 271
Carprofen 204
Bedinvetmab 145
Maropitant Citrate 135
Milbemycin Oxime + Spinosad 129
Trilostane 113
Deracoxib 90
Oclacitinib Maleate 81
Spinosad 78
Fluralaner Chew Tablets 77
Cefovecin 72
Gabapentin 71
Grapiprant 68
Afoxolaner 62
Frunevetmab 62
Firocoxib 60
Buprenorphine 45
Robenacoxib 44
Selamectin 43
Pimobendan 42

Renal failure Reaction Insights

2,160 reports name Renal failure; 1,211 recorded a death outcome (56.1% of reported events, not a population-level mortality rate). VeDDRA code: 720.

By species: Dog (1,545 reports), Cat (584 reports), Horse (16 reports). By breed: Domestic Shorthair (206), Domestic (unspecified) (152), Retriever - Labrador (151).

Most co-reported drugs: Meloxicam (271 reports), Carprofen (204 reports), Bedinvetmab (145 reports), Maropitant Citrate (135 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.