Reaction profile

The FDA adverse-event record for abnormal histology nos

150 FDA adverse-event reports reference abnormal histology nos (VeDDRA 2864). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1183 of 2,481
by report volume (all reactions)
150
reports citing this reaction
32.0%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Abnormal histology NOS has 150 reports now versus 134 in that prior snapshot: 16 more (11.9%).

Report change
+16
Death-coded reports
+5
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Abnormal histology NOS changes

FDA AER · VeDDRA plate

Code 2864 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 150 reports
  • DEATH-HOT 32.0%
  • MID-PACK #1183/2481
  • PHOTO-FINISH Application site exco…
  • SPECIES-DOG Dog · 102
  • DRUG-LEAD Carprofen · 27
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Application site excoriation (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Abnormal histology NOS

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Abnormal histology NOS · thi…150Application site exco… · near150Ligament rupture · near150Nephropathy · near150Quadriparesis · near150Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Abnormal histology NOS

Abnormal histology NOS: high death-coded share in the FDA AER plate

Signature read: Abnormal histology NOS's 32.0% death-coded share is among the highest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 48 of 150 reports (32.0% of named reports). Nearest volume peer: Application site excoriation (±0 reports). Lead species Dog (102). Lead co-reported drug Carprofen (27).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 102
Cat 37
Cattle 5
Sheep 2
Horse 1
Mouse 1
Turkey 1
Pig 1

Breeds Most Affected

Domestic Shorthair 27
Retriever - Labrador 16
Crossbred Canine/dog 10
Retriever - Golden 8
Terrier (unspecified) 4
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 4
Shepherd Dog - German 4
Pinscher - Miniature 4
Chihuahua 4
Shepherd Dog - Australian 4

Associated Drugs

Carprofen 27
Maropitant Citrate 26
Gabapentin 22
Oclacitinib Maleate 22
Bedinvetmab 21
Prednisone 18
Frunevetmab 17
Robenacoxib 14
Fluid Therapy 14
Cefpodoxime 12
Butorphanol 10
Ilunocitinib 10
Meloxicam 9
Dexmedetomidine 9
Rabies Vaccine 9
Cephalexin 9
Trilostane 8
Cyclosporine 8
Bordetella Vaccine 8
Buprenorphine 8

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Abnormal histology NOS, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (150 here).

Similar death-coded share

Nearest other reactions by death-coded share (32.0% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Abnormal histology NOS (#1183 of 2,481 by report volume); death-coded 32.0%. PlainBreed reaction plate · death-coded share stamp 32.0% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →