Reaction profile

The FDA adverse-event record for abnormal histology nos

112 FDA adverse-event reports reference abnormal histology nos (VeDDRA 2864). See the species, breeds, and drugs most associated with it below.

112
reports citing this reaction
31.3%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
112
Total Reports
35
Deaths
31.3%
Death Rate

Species Most Affected

Dog 75
Cat 29
Cattle 4
Horse 1
Mouse 1
Turkey 1
Pig 1

Breeds Most Affected

Domestic Shorthair 21
Retriever - Labrador 11
Retriever - Golden 7
Crossbred Canine/dog 6
Terrier (unspecified) 4
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 4
Shepherd Dog - German 4
Pinscher - Miniature 4
Boxer (German Boxer) 3
Spaniel (unspecified) 3

Associated Drugs

Carprofen 19
Oclacitinib Maleate 19
Gabapentin 15
Frunevetmab 15
Bedinvetmab 15
Prednisone 14
Maropitant Citrate 13
Fluid Therapy 10
Cefpodoxime 9
Trilostane 8
Meloxicam 8
Bordetella Vaccine 8
Robenacoxib 7
Rabies Vaccine 7
Cyclosporine 6
Buprenorphine 6
Cephalexin 6
Cefovecin 5
Anti-Il31 Mab Mcs Lot #1283563 5
Dexmedetomidine 5

Abnormal histology NOS Reaction Insights

112 reports name Abnormal histology NOS; 35 recorded a death outcome (31.3% of reported events, not a population-level mortality rate). VeDDRA code: 2864.

By species: Dog (75 reports), Cat (29 reports), Cattle (4 reports). By breed: Domestic Shorthair (21), Retriever - Labrador (11), Retriever - Golden (7).

Most co-reported drugs: Carprofen (19 reports), Oclacitinib Maleate (19 reports), Gabapentin (15 reports), Frunevetmab (15 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.