Reaction profile

The FDA adverse-event record for hypermetria

194 FDA adverse-event reports reference hypermetria (VeDDRA 662). See the species, breeds, and drugs most associated with it below.

194
reports citing this reaction
13.9%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
194
Total Reports
27
Deaths
13.9%
Death Rate

Species Most Affected

Dog 171
Cat 17
Horse 5
Goat 1

Breeds Most Affected

Retriever - Labrador 17
Chihuahua 15
Domestic Shorthair 14
Retriever - Golden 10
Shepherd Dog - Australian 9
Crossbred Canine/dog 8
Terrier - Yorkshire 7
Maltese 7
Terrier - Jack Russell 6
Shepherd Dog - German 6

Associated Drugs

Milbemycin Oxime + Spinosad 25
Bedinvetmab 21
Afoxolaner 19
Gabapentin 16
Spinosad 12
Carprofen 12
Fluralaner Chew Tablets 12
Sarolaner 11
Maropitant Citrate 9
Pyrantel Pamoate;Sarolaner 9
Ivermectin 8
Moxidectin 7
Selamectin 7
Frunevetmab 7
Ivermectin + Pyrantel As Pamoate Salt 6
Prednisone 6
Fluralaner 13.64% 12-Week Chew 6
Imidacloprid + Moxidectin 4
Grapiprant 4
Dexamethasone 3

Hypermetria Reaction Insights

194 reports name Hypermetria; 27 recorded a death outcome (13.9% of reported events, not a population-level mortality rate). VeDDRA code: 662.

By species: Dog (171 reports), Cat (17 reports), Horse (5 reports). By breed: Retriever - Labrador (17), Chihuahua (15), Domestic Shorthair (14).

Most co-reported drugs: Milbemycin Oxime + Spinosad (25 reports), Bedinvetmab (21 reports), Afoxolaner (19 reports), Gabapentin (16 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.