Reaction profile

The FDA adverse-event record for less social

183 FDA adverse-event reports reference less social (VeDDRA 2411). See the species, breeds, and drugs most associated with it below.

183
reports citing this reaction
14.8%
death-coded share
Dog
most-affected species
Fluralaner Chew Tablets
most-associated drug
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183
Total Reports
27
Deaths
14.8%
Death Rate

Species Most Affected

Dog 97
Cat 84
Other Equids 1
Horse 1

Breeds Most Affected

Domestic Shorthair 54
Crossbred Canine/dog 10
Chihuahua 9
Cat (other) 8
Retriever - Golden 7
Shih Tzu 7
Cat (unknown) 7
Domestic Longhair 5
Domestic Mediumhair 5
Bulldog - French 4

Associated Drugs

Fluralaner Chew Tablets 14
Selamectin 13
Sarolaner 11
Buprenorphine 11
Frunevetmab 9
Oclacitinib Maleate 8
Pyrantel Pamoate;Sarolaner 8
Cefovecin 7
Fluralaner Spot-On Solution 7
Maropitant Citrate 7
Trilostane 7
Selamectin;Sarolaner 6
Lotilaner 5
Fluralaner/Moxidectin Spot-On 5
Fluralaner 13.64% 12-Week Chew 5
Robenacoxib 5
Carprofen 4
Afoxolaner 4
Mirtazapine 4
Isoflurane 4

Less social Reaction Insights

183 reports name Less social; 27 recorded a death outcome (14.8% of reported events, not a population-level mortality rate). VeDDRA code: 2411.

By species: Dog (97 reports), Cat (84 reports), Other Equids (1 reports). By breed: Domestic Shorthair (54), Crossbred Canine/dog (10), Chihuahua (9).

Most co-reported drugs: Fluralaner Chew Tablets (14 reports), Selamectin (13 reports), Sarolaner (11 reports), Buprenorphine (11 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.