Reaction profile

The FDA adverse-event record for polypnoea

1,222 FDA adverse-event reports reference polypnoea (VeDDRA 857). See the species, breeds, and drugs most associated with it below.

1,222
reports citing this reaction
14.2%
death-coded share
Dog
most-affected species
Melarsomine Dihydrochloride
most-associated drug
Verify with FDA CVM →
1,222
Total Reports
174
Deaths
14.2%
Death Rate

Species Most Affected

Dog 1,046
Cat 161
Horse 5
Cattle 5
Goat 2
Sheep 1
Other Deer 1
Rabbit 1

Breeds Most Affected

Crossbred Canine/dog 258
Domestic (unspecified) 134
Retriever - Labrador 100
Retriever - Golden 39
Dog (unknown) 35
Shepherd Dog - German 35
Terrier - Yorkshire 31
Shih Tzu 29
Boxer (German Boxer) 26
Shepherd Dog - Australian 24

Associated Drugs

Melarsomine Dihydrochloride 150
Spinosad 103
Cyclosporine 103
Carprofen 84
Nitenpyram 76
Ivermectin, Pyrantel 63
Deracoxib 50
Selamectin 44
Imidacloprid, Moxidectin 41
Spinosad, Milbemycin 39
Milbemycin 33
Meloxicam 31
Firocoxib 29
Atipamezole 21
Cefovecin Sodium 21
Moxidectin 21
Dexmedetomidine Hydrochloride 19
Milbemycin, Lufenuron 16
Pimobendan 15
Maropitant 13

Polypnoea Reaction Insights

1,222 reports name Polypnoea; 174 recorded a death outcome (14.2% of reported events, not a population-level mortality rate). VeDDRA code: 857.

By species: Dog (1,046 reports), Cat (161 reports), Horse (5 reports). By breed: Crossbred Canine/dog (258), Domestic (unspecified) (134), Retriever - Labrador (100).

Most co-reported drugs: Melarsomine Dihydrochloride (150 reports), Spinosad (103 reports), Cyclosporine (103 reports), Carprofen (84 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.