Reaction profile

The FDA adverse-event record for high blood pressure

567 FDA adverse-event reports reference high blood pressure (VeDDRA 225). See the species, breeds, and drugs most associated with it below.

567
reports citing this reaction
13.1%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
567
Total Reports
74
Deaths
13.1%
Death Rate

Species Most Affected

Dog 410
Cat 105
Human 51
Cattle 1

Breeds Most Affected

Domestic Shorthair 69
Unknown 52
Retriever - Labrador 40
Crossbred Canine/dog 28
Terrier - Yorkshire 20
Shih Tzu 20
Chihuahua 19
Beagle 14
Dachshund (unspecified) 11
Retriever - Golden 10

Associated Drugs

Trilostane 83
Bedinvetmab 49
Milbemycin Oxime + Spinosad 41
Maropitant Citrate 38
Gabapentin 34
Carprofen 31
Prednisone 23
Phenylpropropanolamine Hcl 22
Grapiprant 21
Buprenorphine 19
Amlodipine 17
Pimobendan 17
Butorphanol 17
Tilmicosin 16
Milbemycin Oxime + Praziquantel 16
Pyrantel Pamoate;Sarolaner 16
Moxidectin 15
Frunevetmab 15
Benazepril 14
Diphenhydramine 14

High blood pressure Reaction Insights

567 reports name High blood pressure; 74 recorded a death outcome (13.1% of reported events, not a population-level mortality rate). VeDDRA code: 225.

By species: Dog (410 reports), Cat (105 reports), Human (51 reports). By breed: Domestic Shorthair (69), Unknown (52), Retriever - Labrador (40).

Most co-reported drugs: Trilostane (83 reports), Bedinvetmab (49 reports), Milbemycin Oxime + Spinosad (41 reports), Maropitant Citrate (38 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.