Reaction profile

The FDA adverse-event record for ataxia

20,937 FDA adverse-event reports reference ataxia (VeDDRA 654). See the species, breeds, and drugs most associated with it below.

20,937
reports citing this reaction
12.9%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
20,937
Total Reports
2,692
Deaths
12.9%
Death Rate

Species Most Affected

Dog 15,940
Cat 4,430
Horse 311
Cattle 110
Pig 23
Goat 15
Human 14
Sheep 12
Turkey 10
Chicken 9

Breeds Most Affected

Domestic Shorthair 2,457
Retriever - Labrador 1,475
Crossbred Canine/dog 1,297
Chihuahua 884
Terrier - Yorkshire 708
Retriever - Golden 701
Shepherd Dog - German 585
Shih Tzu 475
Boxer (German Boxer) 466
Domestic (unspecified) 460

Associated Drugs

Milbemycin Oxime + Spinosad 2,731
Bedinvetmab 1,380
Spinosad 1,199
Carprofen 1,032
Sarolaner 1,015
Afoxolaner 990
Pyrantel Pamoate;Sarolaner 919
Maropitant Citrate 782
Imidacloprid + Moxidectin 771
Selamectin 683
Ivermectin 674
Moxidectin 630
Gabapentin 560
Cefovecin 513
Ivermectin + Pyrantel As Pamoate Salt 486
Milbemycin Oxime + Praziquantel 478
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 474
Fluralaner Chew Tablets 444
Emodepside + Praziquantel 386
Fluralaner 13.64% 12-Week Chew 376

Ataxia Reaction Insights

20,937 reports name Ataxia; 2,692 recorded a death outcome (12.9% of reported events, not a population-level mortality rate). VeDDRA code: 654.

By species: Dog (15,940 reports), Cat (4,430 reports), Horse (311 reports). By breed: Domestic Shorthair (2,457), Retriever - Labrador (1,475), Crossbred Canine/dog (1,297).

Most co-reported drugs: Milbemycin Oxime + Spinosad (2,731 reports), Bedinvetmab (1,380 reports), Spinosad (1,199 reports), Carprofen (1,032 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.