Reaction profile

The FDA adverse-event record for enlarged lymph node (localised)

537 FDA adverse-event reports reference enlarged lymph node (localised) (VeDDRA 2405). See the species, breeds, and drugs most associated with it below.

537
reports citing this reaction
19.9%
death-coded share
Dog
most-affected species
Oclacitinib Maleate
most-associated drug
Verify with FDA CVM →
537
Total Reports
107
Deaths
19.9%
Death Rate

Species Most Affected

Dog 444
Cat 86
Horse 4
Cattle 1
Human 1
Other 1

Breeds Most Affected

Retriever - Labrador 58
Domestic Shorthair 50
Crossbred Canine/dog 36
Retriever - Golden 28
Shepherd Dog - German 21
Terrier - Bull - American Pit 21
Boxer (German Boxer) 20
Shih Tzu 16
Beagle 14
Terrier - Yorkshire 10

Associated Drugs

Oclacitinib Maleate 96
Maropitant Citrate 50
Bedinvetmab 48
Carprofen 47
Gabapentin 45
Prednisone 39
Tigilanol Tiglate 29
Anti-Il31 Mab Mcs Lot #1283563 28
Moxidectin 28
Trilostane 25
Fluralaner Chew Tablets 24
Cefovecin 24
Famotidine 24
Frunevetmab 21
Doxycycline 20
Afoxolaner 19
Enrofloxacin 17
Diphenhydramine 17
Prednisolone 16
Pyrantel Pamoate;Sarolaner 16

Enlarged lymph node (localised) Reaction Insights

537 reports name Enlarged lymph node (localised); 107 recorded a death outcome (19.9% of reported events, not a population-level mortality rate). VeDDRA code: 2405.

By species: Dog (444 reports), Cat (86 reports), Horse (4 reports). By breed: Retriever - Labrador (58), Domestic Shorthair (50), Crossbred Canine/dog (36).

Most co-reported drugs: Oclacitinib Maleate (96 reports), Maropitant Citrate (50 reports), Bedinvetmab (48 reports), Carprofen (47 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.