Reaction profile

The FDA adverse-event record for abnormal vision (see also impaired vision)

138 FDA adverse-event reports reference abnormal vision (see also impaired vision) (VeDDRA 1293). See the species, breeds, and drugs most associated with it below.

138
reports citing this reaction
13.8%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
138
Total Reports
19
Deaths
13.8%
Death Rate

Species Most Affected

Dog 97
Cat 25
Human 12
Horse 4

Breeds Most Affected

Retriever - Labrador 16
Domestic Shorthair 16
Unknown 12
Crossbred Canine/dog 9
Chihuahua 7
Boxer (German Boxer) 6
Terrier - Yorkshire 5
Shih Tzu 4
Domestic Longhair 4
Maltese 3

Associated Drugs

Milbemycin Oxime + Spinosad 19
Fluralaner Chew Tablets 10
Ivermectin 9
Afoxolaner 9
Nitenpyram 7
Ivermectin + Pyrantel As Pamoate Salt 7
Spinosad 6
Maropitant Citrate 6
Moxidectin 6
Sarolaner 6
Bedinvetmab 6
Isoflurane 5
Buprenorphine 5
Rabies Vaccine 4
Carprofen 4
Pyrantel Pamoate;Sarolaner 4
Prednisone 3
Butorphanol Tartrate 3
Imidacloprid + Moxidectin 3
Cefovecin 3

Abnormal vision (see also impaired vision) Reaction Insights

138 reports name Abnormal vision (see also impaired vision); 19 recorded a death outcome (13.8% of reported events, not a population-level mortality rate). VeDDRA code: 1293.

By species: Dog (97 reports), Cat (25 reports), Human (12 reports). By breed: Retriever - Labrador (16), Domestic Shorthair (16), Unknown (12).

Most co-reported drugs: Milbemycin Oxime + Spinosad (19 reports), Fluralaner Chew Tablets (10 reports), Ivermectin (9 reports), Afoxolaner (9 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.