Reaction profile

The FDA adverse-event record for low serum alkaline phosphatase (sap)

146 FDA adverse-event reports reference low serum alkaline phosphatase (sap) (VeDDRA 2690). See the species, breeds, and drugs most associated with it below.

146
reports citing this reaction
13.0%
death-coded share
Dog
most-affected species
Ivermectin + Pyrantel As Pamoate Salt
most-associated drug
Verify with FDA CVM →
146
Total Reports
19
Deaths
13.0%
Death Rate

Species Most Affected

Dog 101
Cat 43
Horse 1
Mouse 1

Breeds Most Affected

Domestic Shorthair 28
Crossbred Canine/dog 16
Terrier - Yorkshire 8
Shih Tzu 8
Shepherd Dog - German 8
Retriever - Golden 7
Domestic Longhair 7
Terrier - Boston 4
Chihuahua 4
Schnauzer - Miniature 4

Associated Drugs

Ivermectin + Pyrantel As Pamoate Salt 18
Fluralaner 13.64% 12-Week Chew 17
Afoxolaner 16
Maropitant Citrate 11
Milbemycin Oxime + Spinosad 9
Moxidectin 8
Fluralaner Chew Tablets 7
Cefovecin 7
Fluralaner Spot-On Solution 6
Carprofen 6
Milbemycin Oxime + Praziquantel 6
Robenacoxib 6
Feline Calicivirus, Strain F-9, Passage 7, Lot A;Feline Viral Rhinotracheitis, S 5
Midazolam 5
Buprenorphine 5
Fluralaner/Moxidectin Spot-On 5
Grapiprant 4
Rabies Virus, 4
Prednisone 4
Rabies Vaccine 4

Low serum alkaline phosphatase (SAP) Reaction Insights

146 reports name Low serum alkaline phosphatase (SAP); 19 recorded a death outcome (13.0% of reported events, not a population-level mortality rate). VeDDRA code: 2690.

By species: Dog (101 reports), Cat (43 reports), Horse (1 reports). By breed: Domestic Shorthair (28), Crossbred Canine/dog (16), Terrier - Yorkshire (8).

Most co-reported drugs: Ivermectin + Pyrantel As Pamoate Salt (18 reports), Fluralaner 13.64% 12-Week Chew (17 reports), Afoxolaner (16 reports), Maropitant Citrate (11 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.