Reaction profile

The FDA adverse-event record for soft stool

394 FDA adverse-event reports reference soft stool (VeDDRA 3069). See the species, breeds, and drugs most associated with it below.

394
reports citing this reaction
5.8%
death-coded share
Dog
most-affected species
Bexagliflozin
most-associated drug
Verify with FDA CVM →
394
Total Reports
23
Deaths
5.8%
Death Rate

Species Most Affected

Dog 292
Cat 99
Horse 3

Breeds Most Affected

Domestic Shorthair 69
Retriever - Labrador 31
Crossbred Canine/dog 21
Retriever - Golden 14
Shepherd Dog - German 13
Dog (unknown) 11
Domestic Longhair 11
Beagle 9
Chihuahua 9
Terrier - Yorkshire 9

Associated Drugs

Bexagliflozin 47
Bedinvetmab 38
Maropitant Citrate 36
Pyrantel Pamoate;Sarolaner 33
Gabapentin 27
Carprofen 27
Milbemycin Oxime + Praziquantel 26
Velagliflozin Proline Monohydrate 26
Oclacitinib Maleate 21
Moxidectin 20
Metronidazole 17
Prednisone 17
Diphenhydramine 14
Trilostane 13
Lotilaner 13
Fluralaner 13.64% 12-Week Chew 12
Anti-Il31 Mab Mcs Lot #1283563 12
Lotilaner,Moxidectin,Praziquantel,Pyrantel Pamoate 12
Prescription Diet 11
Ivermectin + Pyrantel As Pamoate Salt 10

Soft stool Reaction Insights

394 reports name Soft stool; 23 recorded a death outcome (5.8% of reported events, not a population-level mortality rate). VeDDRA code: 3069.

By species: Dog (292 reports), Cat (99 reports), Horse (3 reports). By breed: Domestic Shorthair (69), Retriever - Labrador (31), Crossbred Canine/dog (21).

Most co-reported drugs: Bexagliflozin (47 reports), Bedinvetmab (38 reports), Maropitant Citrate (36 reports), Pyrantel Pamoate;Sarolaner (33 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.