Reaction profile

The FDA adverse-event record for hair change

578 FDA adverse-event reports reference hair change (VeDDRA 1506). See the species, breeds, and drugs most associated with it below.

578
reports citing this reaction
4.2%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
578
Total Reports
24
Deaths
4.2%
Death Rate

Species Most Affected

Dog 401
Cat 123
Horse 33
Cattle 15
Human 5
Donkey 1

Breeds Most Affected

Domestic Shorthair 62
Retriever - Labrador 38
Retriever - Golden 34
Crossbred Canine/dog 26
Shih Tzu 19
Domestic Longhair 18
Shepherd Dog - Australian 16
Chihuahua 14
Dog (unknown) 11
Shepherd Dog - German 10

Associated Drugs

Trilostane 60
Milbemycin Oxime + Spinosad 55
Oclacitinib Maleate 49
Prednisone 39
Afoxolaner 35
Selamectin 32
Imidacloprid + Moxidectin 30
Pergolide Mesylate 28
Spinosad 26
Cyclosporine 23
Fluralaner Chew Tablets 23
Cyclosporine A 19
Fluralaner Spot-On Solution 16
Ivermectin + Pyrantel As Pamoate Salt 14
Milbemycin Oxime + Praziquantel 14
Gabapentin 12
Maropitant Citrate 11
Nitenpyram 11
Fluralaner 13.64% 12-Week Chew 11
Levothyroxine 10

Hair change Reaction Insights

578 reports name Hair change; 24 recorded a death outcome (4.2% of reported events, not a population-level mortality rate). VeDDRA code: 1506.

By species: Dog (401 reports), Cat (123 reports), Horse (33 reports). By breed: Domestic Shorthair (62), Retriever - Labrador (38), Retriever - Golden (34).

Most co-reported drugs: Trilostane (60 reports), Milbemycin Oxime + Spinosad (55 reports), Oclacitinib Maleate (49 reports), Prednisone (39 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.