Reaction profile

The FDA adverse-event record for red eye

588 FDA adverse-event reports reference red eye (VeDDRA 1721). See the species, breeds, and drugs most associated with it below.

588
reports citing this reaction
6.0%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
588
Total Reports
35
Deaths
6.0%
Death Rate

Species Most Affected

Dog 509
Cat 45
Human 33
Horse 1

Breeds Most Affected

Retriever - Labrador 57
Crossbred Canine/dog 43
Boxer (German Boxer) 35
Unknown 33
Domestic Shorthair 28
Retriever - Golden 24
Pit Bull 21
Shih Tzu 19
Chihuahua 17
Terrier - Bull - American Pit 14

Associated Drugs

Milbemycin Oxime + Spinosad 110
Moxidectin 61
Afoxolaner 46
Pyrantel Pamoate;Sarolaner 26
Ivermectin + Pyrantel As Pamoate Salt 25
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 25
Spinosad 21
Oclacitinib Maleate 21
Milbemycin Oxime + Praziquantel 20
Maropitant Citrate 18
Imidacloprid + Moxidectin 16
Prednisone 16
Rabies Vaccine 14
Fluralaner Chew Tablets 14
Lotilaner 13
Insulin Injectable Vial 12
Gabapentin 12
Diphenhydramine 11
Selamectin 11
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 11

Red eye Reaction Insights

588 reports name Red eye; 35 recorded a death outcome (6.0% of reported events, not a population-level mortality rate). VeDDRA code: 1721.

By species: Dog (509 reports), Cat (45 reports), Human (33 reports). By breed: Retriever - Labrador (57), Crossbred Canine/dog (43), Boxer (German Boxer) (35).

Most co-reported drugs: Milbemycin Oxime + Spinosad (110 reports), Moxidectin (61 reports), Afoxolaner (46 reports), Pyrantel Pamoate;Sarolaner (26 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.