Reaction profile

The FDA adverse-event record for hyphaemia

146 FDA adverse-event reports reference hyphaemia (VeDDRA 418). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1210 of 2,481
by report volume (all reactions)
146
reports citing this reaction
37.0%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hyphaemia has 146 reports now versus 142 in that prior snapshot: 4 more (2.8%).

Report change
+4
Death-coded reports
+3
Death-coded share
+1.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hyphaemia changes

FDA AER · VeDDRA plate

Code 418 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 146 reports
  • DEATH-HOT 37.0%
  • MID-PACK #1210/2481
  • PHOTO-FINISH Abnormal vision (see…
  • SPECIES-DOG Dog · 118
  • DRUG-LEAD Carprofen · 19
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Abnormal vision (see also impaired vision) (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Hyphaemia

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Abnormal vision (see… · near146Encephalitis · near146Gastric bloat · near146Generalised skin reac… · near146Hyphaemia · this reaction146Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Hyphaemia

Hyphaemia: high death-coded share in the FDA AER plate

Signature read: Hyphaemia's 37.0% death-coded share is among the highest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 54 of 146 reports (37.0% of named reports). Nearest volume peer: Abnormal vision (see also impaired vision) (±0 reports). Lead species Dog (118). Lead co-reported drug Carprofen (19).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 118
Cat 25
Guinea Pig 1
Horse 1
Unknown 1

Breeds Most Affected

Retriever - Labrador 17
Domestic Shorthair 13
Crossbred Canine/dog 10
Siberian Husky 5
Siamese 5
Schnauzer - Miniature 4
Chihuahua 4
Shih Tzu 4
Shepherd Dog - German 4
Retriever - Golden 4

Associated Drugs

Carprofen 19
Prednisone 15
Maropitant Citrate 11
Moxidectin 9
Dexamethasone 8
Oclacitinib Maleate 8
Robenacoxib 8
Gabapentin 8
Bedinvetmab 8
Cefovecin 7
Buprenorphine 7
Enrofloxacin 6
Isoflurane 6
Doxycycline 5
Fluralaner Chew Tablets 5
Pyrantel Pamoate;Sarolaner 5
Phenylpropanolamine 4
Cefovecin Sodium 4
Meloxicam 4
Milbemycin Oxime + Spinosad 4

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Hyphaemia, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (37.0% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hyphaemia (#1210 of 2,481 by report volume); death-coded 37.0%. PlainBreed reaction plate · death-coded share stamp 37.0% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →