Reaction profile

The FDA adverse-event record for hyphaemia

136 FDA adverse-event reports reference hyphaemia (VeDDRA 418). See the species, breeds, and drugs most associated with it below.

136
reports citing this reaction
35.3%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
136
Total Reports
48
Deaths
35.3%
Death Rate

Species Most Affected

Dog 111
Cat 22
Guinea Pig 1
Horse 1
Unknown 1

Breeds Most Affected

Retriever - Labrador 15
Domestic Shorthair 11
Crossbred Canine/dog 7
Siberian Husky 5
Siamese 5
Schnauzer - Miniature 4
Chihuahua 4
Shih Tzu 4
Shepherd Dog - German 4
Retriever - Golden 4

Associated Drugs

Carprofen 17
Prednisone 14
Dexamethasone 8
Maropitant Citrate 8
Oclacitinib Maleate 8
Moxidectin 7
Gabapentin 7
Bedinvetmab 7
Enrofloxacin 6
Robenacoxib 6
Buprenorphine 6
Doxycycline 5
Cefovecin 5
Fluralaner Chew Tablets 5
Phenylpropanolamine 4
Meloxicam 4
Milbemycin Oxime + Spinosad 4
Ampicillin 4
Diphenhydramine 4
Bordetella Vaccine 4

Hyphaemia Reaction Insights

136 reports name Hyphaemia; 48 recorded a death outcome (35.3% of reported events, not a population-level mortality rate). VeDDRA code: 418.

By species: Dog (111 reports), Cat (22 reports), Guinea Pig (1 reports). By breed: Retriever - Labrador (15), Domestic Shorthair (11), Crossbred Canine/dog (7).

Most co-reported drugs: Carprofen (17 reports), Prednisone (14 reports), Dexamethasone (8 reports), Maropitant Citrate (8 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.