Reaction profile

The FDA adverse-event record for head tilt - neurological disorder

622 FDA adverse-event reports reference head tilt - neurological disorder (VeDDRA 2523). See the species, breeds, and drugs most associated with it below.

622
reports citing this reaction
15.4%
death-coded share
Dog
most-affected species
Fluralaner Chew Tablets
most-associated drug
Verify with FDA CVM →
622
Total Reports
96
Deaths
15.4%
Death Rate

Species Most Affected

Dog 490
Cat 122
Rabbit 3
Hamster 1
Other Mammals 1
Pig 1
Cattle 1
Guinea Pig 1
Horse 1
Other Equids 1

Breeds Most Affected

Domestic Shorthair 82
Crossbred Canine/dog 49
Retriever - Labrador 39
Chihuahua 23
Maltese 19
Shepherd Dog - German 19
Boxer (German Boxer) 18
Retriever - Golden 18
Terrier - Yorkshire 14
Beagle 14

Associated Drugs

Fluralaner Chew Tablets 70
Sarolaner 69
Afoxolaner 50
Maropitant Citrate 43
Fluralaner Spot-On Solution 40
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 36
Fluralaner 13.64% 12-Week Chew 33
Ivermectin + Pyrantel As Pamoate Salt 32
Milbemycin Oxime + Spinosad 31
Selamectin 26
Pyrantel Pamoate;Sarolaner 25
Trilostane 20
Cefovecin 18
Carprofen 18
Oclacitinib Maleate 18
Prednisone 18
Moxidectin 18
Milbemycin Oxime + Praziquantel 17
Grapiprant 16
Lotilaner 16

Head tilt - neurological disorder Reaction Insights

622 reports name Head tilt - neurological disorder; 96 recorded a death outcome (15.4% of reported events, not a population-level mortality rate). VeDDRA code: 2523.

By species: Dog (490 reports), Cat (122 reports), Rabbit (3 reports). By breed: Domestic Shorthair (82), Crossbred Canine/dog (49), Retriever - Labrador (39).

Most co-reported drugs: Fluralaner Chew Tablets (70 reports), Sarolaner (69 reports), Afoxolaner (50 reports), Maropitant Citrate (43 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.