Elevated creatine-kinase (CK)

VeDDRA Code: 2245

995 adverse event reports referencing this reaction

995

Total Reports

225

Deaths

2260.0%

Death Rate

Species Most Affected

Dog 709

Cat 202

Horse 66

Human 6

Cattle 6

Pig 2

Sheep 1

Other Birds 1

Hedgehog 1

Wolf 1

Breeds Most Affected

Domestic Shorthair 129

Retriever - Labrador 82

Crossbred Canine/dog 67

Retriever - Golden 32

Chihuahua 28

Quarter Horse 25

Domestic (unspecified) 25

Collie - Border 21

Shepherd Dog - German 19

Beagle 16

Associated Drugs

Afoxolaner 81

Carprofen 77

Trilostane 75

Maropitant Citrate 71

Oclacitinib Maleate 51

Fluralaner Chew Tablets 51

Ivermectin + Pyrantel As Pamoate Salt 48

Bedinvetmab 38

Cefovecin 37

Gabapentin 35

Moxidectin 33

Milbemycin Oxime + Spinosad 31

Meloxicam 30

Prednisone 28

Fluralaner 13.64% 12-Week Chew 27

Deracoxib 23

Buprenorphine 22

Isoflurane 22

Frunevetmab 22

Enrofloxacin 21

Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.