Reaction profile

The FDA adverse-event record for licking at application site

1,018 FDA adverse-event reports reference licking at application site (VeDDRA 1973). See the species, breeds, and drugs most associated with it below.

1,018
reports citing this reaction
1.2%
death-coded share
Cat
most-affected species
Imidacloprid + Moxidectin
most-associated drug
Verify with FDA CVM →
1,018
Total Reports
12
Deaths
1.2%
Death Rate

Species Most Affected

Cat 923
Dog 89
Cattle 3
Horse 3

Breeds Most Affected

Domestic Shorthair 612
Cat (unknown) 92
Domestic Longhair 65
Domestic Mediumhair 50
Siamese 29
Cat (other) 13
Crossbred Canine/dog 9
Russian 8
Bengal 8
Maine Coon 7

Associated Drugs

Imidacloprid + Moxidectin 238
Emodepside + Praziquantel 217
Fluralaner Spot-On Solution 194
Eprinomectin + Esafoxolaner + Praziquantel 103
Selamectin 78
Fluralaner/Moxidectin Spot-On 43
Selamectin;Sarolaner 40
Eprinomectin + Praziquantel 12
Buprenorphine 9
Flumethrin-Imidacloprid 7
Rabies Vaccine 7
Chlorhexidine + Ophytrium 7
Imidacloprid + Pyriproxyfen 6
Ivermectin + Pyrantel As Pamoate Salt 6
Nitenpyram 6
Dexmedetomidine 6
Robenacoxib 6
Cefovecin Sodium 6
Gabapentin 5
Neomycin Sulfate Equivalent To Neomycin Base + Nystatin + Thiostrepton + Triamcinolone Acetonide 5

Licking at application site Reaction Insights

1,018 reports name Licking at application site; 12 recorded a death outcome (1.2% of reported events, not a population-level mortality rate). VeDDRA code: 1973.

By species: Cat (923 reports), Dog (89 reports), Cattle (3 reports). By breed: Domestic Shorthair (612), Cat (unknown) (92), Domestic Longhair (65).

Most co-reported drugs: Imidacloprid + Moxidectin (238 reports), Emodepside + Praziquantel (217 reports), Fluralaner Spot-On Solution (194 reports), Eprinomectin + Esafoxolaner + Praziquantel (103 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.